Bendall, Andrew - University of Guelph - Department of Molecular & Cellular Biology

个人简介

Captivated by natural history from an early age, my professional interest in biology was first kindled as an undergraduate in Australia's bush capital, taking upper level courses in biochemistry, molecular biology, and zoology. An early grounding in molecular biology followed as an honours student at the John Curtin School of Medical Research at the ANU. My Ph.D. training at the CSIRO Laboratory of Biomolecular Engineering in Sydney, was in the transcriptional control of eukaryotic gene expression, with emphasis on the DNA binding specificity of mammalian transcription factors. I then moved to the United States where I applied my knowledge of gene regulatory mechanisms to the developing vertebrate embryo. With a postdoctoral award from the American Heart Association, I developed strategies for misexpression of regulatory genes in the chicken embryo as an invivo model system in which to study the regulation of gene expression, cell differentiation, and tissue patterning during vertebrate embryogenesis. My laboratory continues to use this experimental strategy, among others, to investigate the molecular mechanisms of animal development. Education B.Sc. Australian National University Ph.D. Macquarie University (Sydney)

研究领域

Homeobox genes encode a large and vitally important family of embryonically expressed transcription factors that regulate the essential processes of development. We are currently investigating the Dlx gene family during chick and mouse development. Unravelling the functions and mechanisms of action of this multi-member homeobox family promises to reveal larger truths about the cell-type specificity of protein function, the nature of functional redundancy, the acquisition of novel protein functions, and the evolution of animal bodies. The chicken embryo has a distinguished history in developmental biology as a model vertebrate organism for the ability of investigators to manipulate embryonic tissues and, more recently, levels of gene activity. For us, the chicken embryo holds a central position in our attempts to decipher the mechanisms that regulate gene expression, cell fate, and morphogenesis. We combine in vivo experiments like retroviral-mediated transgenesis in chicken embryos with in vitro and cellular studies that, together, define the biochemical basis for biological functions. These studies are often complemented with molecular genetic approaches in the mouse. Current projects include: Defining the function of Dlx genes in chondrocyte differentiation Investigating Dlx-mediated craniofacial patterning Identifying novel Dlx co-factors Structure-function analyses of Dlx-mediated transcription

近期论文

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Quach, A. MacKenzie, R.K. & Bendall, A.J. (2016) Measuring inputs to a common function: The case of Dlx5 and Dlx6. Biochem. Biophys. Res. Comm. 478: 371-377 Bendall, A.J. (2016) Direct evidence of allele equivalency at the Dlx5/6 locus. Genesis 54(5): 272-276 Haq, K., Wootton, S., Barjeste, N., Golovan, S., Bendall, A.J. & Sharif, S. (2015) Studying the effects of interferon-gamma knockdown on vaccine-induced immunity against Marek’s disease in chickens. Can. J. Vet. Res. 79(1): 1-7 Haq, K., Wootton, S., Barjeste, N., St. Paul, M., Golovan, S., Bendall, A.J. & Sharif, S. (2013) Small interfering RNA-mediated knockdown of chicken interferon-gamma expression. J. Interferon Cytokine Res. 33(6): 319-327 Hawley, S.P, Wills, M.K.B., Rabalski, A.J., Bendall, A.J. & Jones, N. (2011) Expression patterns of ShcD and Shc family adaptor proteins during mouse embryonic development. Dev. Dyn. 240(1): 221-231 Gordon, C.T., Brinas, I.M.L., Rodda, F.A., Bendall, A.J., & Farlie, P.G. (2010) Role of Dlx genes in craniofacial morphogenesis: Dlx2 influences skeletal patterning by inducing ectomesenchymal aggregation in ovo. Evol. Develop. 12(5): 459-473 Zhu, H. & Bendall, A.J. (2009) Dlx5 is a cell-autonomous regulator of chondrocyte hypertrophy in mice and functionally substitutes for Dlx6 during endochondral ossification. PLoS ONE 4(11): e8097 Coubrough, M.L. & Bendall, A.J. (2006) Impaired nuclear import of mammalian Dlx4 proteins as a consequence of rapid sequence divergence. Exp. Cell Res. 312(19):3880-3891 Hsu, S-h.C., Noamani, B., Abernethy, D.E., Zhu, H., Levi, G., & Bendall, A.J. (2006) Dlx5- and Dlx6-mediated chondrogenesis: differential domain requirements for a conserved function. Mech. Dev. 123(11): 819-830