Woo, Patrick - University of Guelph - Department of Integrative Biology

个人简介

B.Sc. - University of British Columbia M.Sc. - University of British Columbia Ph.D. - University of Guelph MRC Postdoctoral Fellow and Ballard Fellow @ the Ontario Veterinary College, U of G, Canada FAO Andre Mayer Research Fellow @ the East African Trypanosomiasis Research Organisation, Uganda, and @ the Serengeti Research Institute, Tanzania IDRC Research Consultant and Visiting Scientist @ the Nigerian Institute for Trypanosomiasis Research, Nigeria

研究领域

Patrick Woo has always focused his research (both basic and applied) on parasitic flagellates in animals including those that are of medical (e.g. Trypanosoma, Giardia) and economic (e.g. Cryptobia, Spironucleus) importance. Over the years he and many of his research projects were sponsored by numerous national and/or international agencies and which allowed him to work and interac with colleagues in several developing and developed countries (in Africa, Asia, Europe, North and South America); e.g. prior to his academic appointment at UofG, his research (supported by four sponsors) was on trypanosomiasis in humans and other animals with field studies in East and West Africa. He initiated and developed two other research programs [one on fish pathogens/diseases (e.g. Cryptobia, Spironucleus) and the other on the taxonomy and biology of protozoan parasites in animals [fishes to mammals] in 1974 after his academic appointment. The two programs with contributions from highly dedicated and talented collaborators (e.g. graduate students, postdoctoral fellows) have enjoyed continuous NSERC support, and also sponsorships from other agencies (e.g. Networks of Centre of Excellence of Canada) since their inceptions. The major component of his fish pathogen/disease program is on Cryptobia and cryptobiosis which is multidisciplinary, and its four major areas of emphases are: biology of the pathogen (e.g. transmission; ultrastructure and multiplication; nutritional requirements; respiration and related enzymes; glucocorticoid receptors on and in Cryptobia) elucidation of host-parasite relationships (e.g. clinical signs as they relate to pathophysiology of the disease; mechanisms of anemia, anorexia and immunodepression in infected fish; utilization of host's cortisol as a 'reproductive' hormone by the pathogen; innate protection in Cryptobia-resistant and Cryptobia-tolerant salmonids; humoral and cell-mediated responses in Cryptobia-susceptible salmonids cryptobiosis (e.g. clinical signs; histopathology; pathophysiology and disease mechanism which includes identification of the 200 kDa metalloprotease as the disease-causing factor; isolation, purifaction and characterization of the metalloprotease, sequence the gene) development of 'proof-of-concept' strategies against the pathogen and disease (e.g. produced a monoclonal antibody [against the 200 kDa glycoprotein] that is therapeutic, and it also inhibits aerobic respiration and multiplication of Cryptobia; selective breeding of Cryptobia-resistant and Cryptobia-tolerant salmonids; two effective vaccines [an attenuated live vaccine and a metalloprotease-DNA vaccine] against the pathogen; chemotherapy and immunochemotherapy of infected fish).

近期论文

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1. Papers in Refereed Journals: MacDonald, L., Alderman, S., Kramer, S., Woo, P.T.K. & Bernier, N. 2014. Hypoxaemia-induced leptin secretion: a mechanism for the control of food intake in diseased fish. J. Endocrinol. 221: 441-455. Li, M. & Woo, P.T.K. 2014. Glucocorticoid receptors on and in a unicellular organism, Cryptobia salmositica. Internat'l. J. Parasitol. 44: 205-210. Woo, P.T.K. & Ardelli, B.F. 2014. Immunity against selected piscine flagellates. Develop. Comp. Immunol. 43(2): 268-279 (invited review). 2. Book Chapters: Jung, S.J. & Woo, P.T.K. 2012. Miaminensis avidus and related species. In: Fish Parasites: Pathobiology and Protection, (eds. P.T.K. Woo & K. Buchmann), CABI, Oxfordshire, U.K. pp.73-91. Woo, P.T.K. 2012. Cryptobia (Trypanoplasma) salmositica. In: Fish Parasites: Pathobiology and Protection, (eds. P.T.K. Woo & K. Buchmann), CABI, Oxfordshire, U.K. pp. 30-54. Woo, P.T.K. 2007. Strategies against piscine parasitosis: the Cryptobia model. In: Innovations and Technologies in Oceanography for Sustainable Development, pp 17-28 (invited review - presented @ the International Conference on Innovations and Technologies on Oceanography for Sustainable Development, Kuala Lumpur, Malaysia). 3. Books: Woo P.T.K. & Iwama, G.K. (eds.), Climate Change and Non-infectious Fish Disorders, CABI, U.K. (in preparation). Woo P.T.K. & Cipriano R. (eds.), 2016. Fish Viruses and Bacteria: Pathobiology and Protection, CABI, U.K. (in press). Woo P.T.K. & Bruno D.W. (eds.), 2014. Diseases and Disorders of Finfish in Cage Culture, 2nd edition, CABI, U.K., 354 pages. Woo P.T.K. & Noakes D.J. (eds.), 2014. Salmon: Biology, Ecological Impacts and Economic Importance, Nova Science Publishers, U.S.A., 355 pages. 4. Special Journal Issue: Woo P.T.K. & Cain, K. (eds.), 2013. Current and Emerging Diseases/Disorders of Fish in Aquaculture, Journal of Aquaculture Research and Development (JARD), OMICS, USA. doi:10.4172/2155-9546.S2-e001