Griswold, Cortland - University of Guelph - Department of Integrative Biology

个人简介

B.Sc. – University of Wisconsin-Madison M.Sc. – University of Toronto Ph.D. – University of British Columbia

研究领域

Broadly my research group's interests are in theoretical biology, with a focus on evolutionary genetics and evolutionary theory. A principal goal of my research group is to characterize processes that determine the evolution of multivariate diversity in nature. We have shown that a useful framework in which to understand the evolution of multivariate diversity is the ancestral graph structure of genetic inheritance. Over the past few years, we have characterized interesting combinatorial properties of genetic interactions (epistasis) in the context of the ancestral graph structure of genetic inheritance. This mapping of epistasis on an ancestral graph may have important consequences for the evolution of multivariate diversity. Presently, we are expanding our study of interactions from genetic to individual to species and ecosystem levels, within an ancestral graph framework. Besides the study of multivariate diversity, projects by students and postdocs in the lab include theoretical analyses of the evolutionary ecology of ring species, the evolution of mutation rates, and modelling compensatory molecular evolution. Collaborative projects in the lab have included modelling the the ecology and evolution of seasonal populations and methods to improve plant breeding.

近期论文

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Griswold, C.K. 2015. Additive genetic variation and evolvability of a multivariate trait can be increased by epistatic gene action. Journal of Theoretical Biology 387: 241-257. Griswold, C.K. 2015. Epistasis can accelerate adaptive diversification in haploid asexual populations. Proceedings of the Royal Society B 282: 20142648. Betini, G.S., A. Pardy, C.K. Griswold, and D.R. Norris. 2015. Causes and consequences of density-dependent dispersal: the role of seasonality and carry-over effects. Ecosphere 6: 1-9. House, M.A., C.K. Griswold and L. Lukens. 2014. Evidence for selection on gene expression in cultivated rice (Oryza sativa). Molecular Biology & Evolution 31: 1414-1525. Betini, G.S., C.K. Griswold, L. Prodan and D.R. Norris. 2014. Body size, carry-over effects and survival in a seasonal environment: consequences for population dynamics. Journal of Animal Ecology 83: 1313-1321. McKay, P.B. and C.K. Griswold. 2014. A comparative study indicates both positive and purifying selection within ryanodine receptor (RyR) genes, as well as correlated evolution. Journal of Experimental Zoology Part A: Ecological Genetics & Physiology 321: 151-163. Betini, G.S., C.K. Griswold, and D.R. Norris. 2013. Density-mediated carry-over effects explain variation in breeding output across time in a seasonal population. Biology Letters 9: 20130582. Betini, G.S., C.K. Griswold, and D.R. Norris. 2013. Carry-over effects, sequential density dependence and the dynamics of populations in a seasonal environment. Proceedings of the Royal Society B 280: 20130110. Griswold, C.K. and T.A. Henry. 2012. Epistasis can increase multivariate trait diversity in haploid non-recombining populations. Theoretical Population Biology 82: 209-221. Griswold, C.K. and D.J. Eisner. 2012. The mapping of epistatic effects onto a genealogical tree in haploid populations. Theoretical Population Biology 81: 32-44. Griswold, C.K. 2011. A Model of the Physiological Basis of a Multivariate Phenotype that is Mediated by Ca2+ Signaling and Controlled by Ryanodine Receptor Composition. Journal of Theoretical Biology 282: 14-22.