Gillis, Todd - University of Guelph - Department of Integrative Biology

个人简介

My interest in biology derives from having spent most of my summers growing up in, or on, the waters surrounding Tobermory, Ontario. These interests led me to study marine biology at the University of Guelph where I became fascinated by the biochemical and physiological adaptations that allow animals to live under extreme environments. I completed an MSc with Dr. Jim Ballantyne at Guelph looking at temperature adaptation in gill mitochondrial membranes from Arctic and temperate marine bivalves. My PhD, with Dr. Glen Tibbits at Simon Fraser University, focused upon the mechanisms that enable cardiac function in trout at their comparatively low physiological temperature. This work specifically focused on the structure-function relationships of a protein called troponin C that enable it to work at low temperatures. As a NSERC Post-Doctoral Fellow in the lab of Dr. Mike Regnier in the Department of Bioengineering at the University of Washington, I worked on a variety of projects looking at the thin filament regulatory proteins and their role in controlling cardiac contractility. Here at Guelph my research program is focused upon the vertebrate heart and the mechanisms that regulate its function. The underlying theme of this work is the evolution of protein structure and function and the role this plays in determining the physiological scope of organisms. B.Sc. - Guelph 1994 M.Sc. - Guelph 1996 Ph.D. - Simon Fraser University 2002 Post-Doctoral Fellow, Department of Bioengineering, University of Washington 2002-2005

研究领域

My research program utilizes a comparative approach to examine the cellular mechanisms underpinning cardiac function in vertebrates and how these can be modified to manipulate physiological capability. Specific questions being addressed include: i) How has the regulation of muscle contraction evolved? ii) What are the molecular mechanisms underlying the remodeling capacity of the fish heart? iii) How does the hagfish heart keep working during prolonged periods of anoxia? iv) What are the consequences of bitumen exposure on the development and function of the salmonid heart?

近期论文

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Keen, A., Klaiman J.M., Shiels, H.A and Gillis T.E. Temperature induced cardiac remodeling in ectotherms. INVITED REVIEW, Journal of Experimental Biology. (2016) doi: 10.1242/jeb.128496 Sears, E.J. and Gillis T.E. A functional comparison of cardiac troponin C from representatives of three vertebrate taxa: linking phylogeny and protein function. Journal of Comparative Biochemistry and Physiology (B), (2016), doi: 10.1016/j.cbpb.2016.07.004. Alderman, S.L., Lin, F., Farrell, A.P., Kennedy, C. and Gillis T.E. Effects of diluted bitumen exposure on juvenile sockeye salmon: from cells to performance. Environmental Toxicology and Chemistry. (2016) doi: 10.1002/etc.3533. Gillis, T.E., Klaiman, J.M., Foster A, Platt MJ, *Huber JS, Corso MY, and Simpson J.A.C. Dissecting the role of the myofilament in diaphragm dysfunction during the development of heart failure in mice. American Journal of Physiology, Heart and Respiratory Physiology, 310, H572-H586 (2016) Gillis, T.E., Regan, M.D., Cox, G.K., Hartner, T.S., Brauner, C.J., Richards, J.G. Farrell A.P. Characterizing the influence of anoxia exposure on the isolated hagfish heart. Journal of Experimental Biology. 218: 3754-3761 (2015) Klaiman, J.M., Pyle, W.G. and Gillis, T.E. Cold acclimation increases cardiac myofilament function and ventricular pressure generation in trout. Journal of Experimental Biology 217, 4132-4140 (2014) Johnson, A.C., Turko, A.J., Klaiman, J.M., Johnston, E.F. and Gillis, T.E. Cold acclimation alters the connective tissue content of the zebrafish (Danio rerio) heart. Journal of Experimental Biology (2014). Pinto, N., Yang, F.C., Negishi, A., Rheinstadter, M.C., Gillis, T.E. and Fudge, D.S. Self-assembly enhances the strength of fibres made from vimentin intermediate filament proteins. Biomacromolecules 10; 15, 574-581 (2014) Johnston, E.F., Alderman, SL. and Gillis, T.E. Chronic hypoxia exposure of trout embryos alters swimming performance and cardiac gene expression in larvae. Physiological and Biochemical Zoology 86, 567-575 (2013). Smith, G.S.T., Samborska, B., Hawley, S.P., Klaiman, J.M., Gillis, T.E., Jones, N., Boggs, J.M. and Harauz, G. Nuclear-localized 21.5-kDa myelin basic protein promotes oligodendrocyte proliferation and neurite outgrowth in co-culture unlike the plasma membrane-associated 18.5-kDa isoform. Journal of Neural Biology 91, 349-362. (2013) Negishi, A., Armstrong, C., Kreplak, L., Rheinstadter, M., Lim, L., Gillis, T.E. and Fudge, D.S. The production of fibers and films from solubilized hagfish slime thread proteins. Biomacromolecules 13, 3475-3482 (2012). Alderman, S.L., Klaiman, J.M., Deck, C.A. and Gillis, T.E. Effect of cold acclimation on troponin I isoform expression in striated muscle of rainbow trout. American Journal of Physiology 303, R168-R176. (2012) Gillis, T.E. Evolution of the regulatory control of the vertebrate heart; the role of the contractile proteins. Book chapter in Ontogeny and Phylogeny of the vertebrate heart. Springer, Tobias Wang Editor. (2012) Klaiman, J.M., Fenna, A.J., Shiels, H.A., Macri, J. and Gillis, T.E. Cardiac remodeling in fish: Strategies to maintain heart function during temperature change. Plos One 6(9): e24464. Epub (2011). Miller, S.C., Gillis, T.E. and Wright, P.A. The ontogeny of regulatory control of the rainbow trout (Oncorhynchus mykiss) heart and how this is influenced by chronic hypoxia exposure Journal of Experimental Biology 214, 1989-1996 (2011).