Tam, William - University of Guelph - Department of Chemistry

个人简介

NSERC PDF (Harvard University, USA, 1997) NSERC PDF (Imperial College, UK, 1996) Ph.D. (University of Toronto, Canada, 1995) B.Sc. (University of Hong Kong, 1990) July 2008 – Present: Full Professor July 2003 – June 2008: Associate Professor December 2001 – June 2003: Assistant Professor (Tenured) January 1998 – December 2001: Assistant Professor

研究领域

The discovery and development of new chemical reactions is a major focus of research activity in organic chemistry. The classes of reactions which have found the broadest applicability in organic chemistry are those that address the issues of regio-, stereo- and enantiocontrol. Reactions which form multiple bonds, rings, and stereocenters are particularly important tools for the efficient assembly of complex molecular structures. The objective of our research program is to develop new methodologies in organic synthesis to construct complex organic molecules with high regio-, stereo- and enantiocontrol. Investigation on novel synthetic methodologies for the construction of different ring systems, including: nitrogen-containing heterocyclic compounds, spirocyclic compounds, attached-ring compounds and polycyclic compounds, is of particular interest. These ring systems are present in many biologically important natural products, which have found use in anti-HIV, anticancer, antiviral and antiretroviral researches. The Tam Research Group is interested in several areas of Synthetic Organic Chemistry, including: The Use of Transition Metal Catalysts in Organic Synthesis Novel Cycloaddition Reactions The Chemistry of Bicyclic Alkenes Ring-forming and ring-opening reactions Synthesis of Novel Chiral Ligands & their Applications in Asymmetric Synthesis Studies on Remote Substituent Effects and Long-Range Stereoelectronic Effects Synthesis of Novel Organic Polymers Natural Product Synthesis

近期论文

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123. Emily Carlson, Daniel Hong and William Tam*. “Type 2 Ring-Opening Reactions of Cyclopropanated 7-Oxabenzonorbornadienes with Carboxylic Acid Nucleophiles” Synthesis 2016, 48, accepted for publication. 122. Emily Carlson and William Tam* “Synthesis of Cyclopropanated 7-Azabenzonorbornadienes” Synthesis 2016, 48, 2449–2454. 121. Emily Carlson and William Tam* “Type 1 Ring-Opening Reactions of Cyclopropanated 7-Azabenzonorbornadienes with Organocuprates” Org. Lett. 2016, 18, 2134–2137. 120. Alan J. Lough, Emily Carlson and William Tam* “(1aR, 2R, 7S, 7aS)-rel-1a,2,7,7a-Tetrahydro-3,6-dimethoxy-2-methyl-2,7-epoxy-1H-cyclopropa[b]naphthalene” 2016 119. Michael Edmunds, Mohammed Abdul Raheem, Rebecca Boutin, Katrina Tait and William Tam*. 2016. “Regioselective palladium catalyzed ring-opening reactions of C1 substituted oxabicyclo[2,2,1]hepta-2,5-diene-2,3-dicarboxylates” Beil. J. Org. Chem. 2016, 12, 239–244. 118. Emily Carlson, Guillaume Duret, Nicolas Blanchard, and William Tam* “Synthesis of Cyclopropanated [2.2.1] Heterobicycloalkenes: An Improved Procedure” Synth. Commun. 2016, 46, 55–62. 117. Michael Edmunds, Michelle L. Menard and William Tam* “Study on the Regioselectivity of Rhodium-Catalyzed Ring Opening Reactions of C1 Substituted 7-Oxabenzonorbornadienes with Boronic Acids” Synth. Commun. 2015, 45, 468–476.