研究领域

Biochemistry/Inorganic & Materials Chemistry/Physical Chemistry

Wide Angle X-ray Diffraction (WAXD) of Spider silk dragline fibers. Published in Soft Matter 2012. Prof. Jeff Yarger's research program is interested in understanding the role that local structure and dynamics plays in controlling the physical and mechanical properties of a wide range of technologically and biologically important, but disordered, materials. Systems currently under investigation include spider silk fibers and biopolymers, protein clusters, polyamorphic materials, nano-particles and quantum dots, battery and fuel cell materials, and most recently diabetes related research. Most of this research is highly interdisciplinary and many projects involve collaborations with the Advanced Photon Source at Argonne National Laboratory, the Spallation Neutron Source at Oak Ridge National Laboratory, and with other faculty in Chemistry and Biochemistry, Materials Science, Physics and Molecular Biology. Central to ongoing research is the use and development of solid-state NMR and MRI techniques applied to elucidate local structure and dynamics in disordered materials. Molecular structures within Spider Dragline Silk proteins. Spider silk is a remarkable biopolymer, a light weight protein fiber which spiders produce for diverse purposes including web structure, prey immobilization, making egg cases and are a key to their survival. With a unique combination of high elasticity, mechanical strength and toughness, its superior material properties surpass those of any currently known man-made fiber. In addition, these fibers are biocompatible and biodegradable. It is one of the best examples of block copolymers in Nature in which repeating structural motifs are linked together covalently resulting in polymers that organize themselves into a variety of nano-structures with exceptional material properties. The figures and illustrations shown on the web page provide some recent examples of NMR, X-ray, Raman, IR and Brillouin results by our research group. These results are published in several papers and are examples of our groups' efforts to understand the mechanical and physical properties of spider silks at the molecular level. Organic and Bioorganic ligand capped nanomaterials is another major research thrust within the group. Specifically, we are exploring the ligand capping chemistry of metal, metal oxide and semiconducting nanoparticles and quantum dots at the molecular level. The group is developing new NMR, X-ray and laser light scattering instruments and methods for elucidating the molecular structure of nanomaterials. For example, Gold nanoparticles (1-5 nm diameter AuNPs) capped with organic ligands are frequently used in catalysis, biomedicine and nanotechnology. Below is a figure from a resent paper where our group developed a facile synthesis for trioctylphosphine capped gold (Au) nanoparticles. Prof. Jeff Yarger's research program has research labs in ISTB1 on the Tempe Campus as ASU. This is also the location of the Magnetic Resonance Research Center, which Prof. Yarger is the founding director. I picture of our research group and collaborators at ASU is shown with everyone on the staircase of our 800 MHz NMR system. Besides labs at ASU, part of Prof. Yarger's group is at Argonne National Labs and at the Spallation Neutron Source at ORNL.

近期论文

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Tarakeshwar, Pilarisetty; Palma, Julio, L.; Holland, Gregory, P.; Fromme, Petra; Yarger, Jeffery L.; Mujica, Vladimiro; Probing the Nature of Charge Transfer at Nano-Bio Interfaces: Peptides on Metal Oxide Nanoparticles. J. Phys. Chem. Lett., 5, 3555-3559 (2014). Addison, Bennett; Weber, Warner; Mou, Qiushi; Holland, Gregory P.; Yarger, Jeffery L.; Structural Characterization of Caddisfly Silk with Solid-State NMR and X-Ray Diffraction. Biophysical Journal, 106(2,S1), 227A (2014). Xu, Dian; Yarger, Jeffery L.; Holland, Gregory P.; Are Spider Silk Proteins a New Class of Intrinsically Disordered Proteins? Biophysical Journal, 106(2,S1), 686A (2014). Xu, Dian; Yarger, Jeffery L.; Holland, Gregory P.; Exploring the Backbone Dynamics of Native Spider Silk Proteins in Black Widow Silk Glands with Solution-state NMR Spectroscopy. Polymer, 55(16), 3879-3885 (2014). [DOI: 10.1016/j.polymer.2014.06.018] Addison, Bennett J.; Popp, Tom Osborne; Weber, Warner S.; Edgerly, Janice S.; Holland, Gregory P.; Yarger, Jeffery L.; Structural Characterization of Nanofiber Silk Produced by Embiopterans (Webspinners). RSC Advances, 4(78), 41301-41313 (2014). Addison, Bennett; Weber, Warner; Mou, Qiushi; Ashton, Nicholas N.; Stewart Russell J.; Holland, Gregory P.; Yarger, Jeffery L.; Reversible Assembly of -Sheet Nanocrystals within Caddisfly Silk. Biomacromolecules, 15(4) 1269-1275 (2014) [DOI: 10.1021/bm401822p]. Shi, Xiangyan; Yarger, Jeffery L.; Holland, Gregory P.; Elucidating Proline Dynamics in Spider Dragline Silk Fibre Using 2H-13C HETCOR MAS NMR. Chem Commun. 50(37), 4856-4859 (2014). Albertson, A.E.; Teulé, F.; Weber, W.; Yarger, J.L.; Lewis, R.V., Effects of Different Post-Spin Stretching Conditions on the Mechanical Properties of Synthetic Spider Silk Fibers. Journal of the Mechanical Behavior of Biomedical Materials, 29, 225-234 (2014). Adrianos, S.L.; Teulé, F.; Hinman, M.B; Jones, J.A.; Weber, W.; Yarger, J.L.; Lewis, R.V., Nephila clavipes Flagelliform Silk-Like GGX Motifs Contribute to Extensibility and Spacer Motifs Contribute to Strength in Synthetic Spider Silk Fibers. Biomacromolecules 14(6), 1751-1760 (2013). [DOI: 10.1021/bm400125w] Holland, Gregory P.; Mou, Qiushi; Yarger, Jeffery L., Determining Hydrogen-Bond Interactions in Spider Silk with 1H-13C HETCOR Fast MAS Solid-State NMR and DFT Proton Chemical Shift Calculations. Chem. Comm. 49(59) 6680-6682 (2013). [DOI: 10.1039/C3CC43737J] Weber, J.K.R.; Benmore, C.J.; Tailor, A.N.; Tumber, S.K.; Neuefeind, J.; Cherry, B.; Yarger, J.L.; Mou, Q.; Weber, W.; Byrn, S.R., A Neutron-X-ray, NMR and Calorimetric Study of Glassy Probucol Synthesized Using Containerless Techniques. Chemical Physics 424, 89-92 (2013). [http://dx.doi.org/10.1016/j.chemphys.2013.05.019] Sampath, Sujatha; Jenkins, Janelle; Butler, Emily; Kim, Jihyun; Henning, Robert; Holland, Gregory; Yarger, Jeffery L., Characterizing the Secondary Protein Structure of Black Widow Dragline Silk Using Solid-State NMR & X-ray Diffraction. Biomacromolecules 14, 3472-3483 (2013). [DOI: dx.doi.org/10.1021/bm400791u] Sampath, Sujatha; Jenkins, Janelle; Butler, Emily; Kim, Jihyun; Henning, Robert; Holland, Gregory; Yarger, Jeffery L., Characterizing the Secondary Protein Structure of Black Widow Dragline Silk Using Solid-State NMR & X-ray Diffraction. Biomacromolecules 14, 3472-3483 (2013). [DOI: dx.doi.org/10.1021/bm400791u] Asakura, Tetsuo; Suzuki, Yu; Nakazawa, Yasumoto; Holland, Gregory P.; Yarger, Jeffery L., Elucidating Silk Structure Using Solid-State NMR. Soft Matter 9, 11440-11450 (2013). [DOI: 10.1039/c3sm52187g] Huang, W.; Angell, A.; Yarger, Jeffery L.; Richert, R., Measurement of Conductivity and Permittivity of Samples Sealed in Nuclear Magnetic Resonance Tubes. Review of Scientific Instrumentation 84, 073906 (2013). [DOI: 10.1063/1.4816134] Shi, Xiangyan; Holland, Gregory P.; Yarger, Jeffery L., Amino Acid Analysis of Spider Dragline Silk Using 1H NMR. Analytical Biochemistry 440, 150-157 (2013). [DOI: http://dx.doi.org/10.1016/j.ab.2013.05.006] Shi, Xiangyan; Yarger, Jeffery L; Holland, Gregory P., Probing Site-Specific 13C/15N-Isotope Enrichment of Spider Silk with Liquid-State NMR Spectroscopy. Analytical and Bioanalytical Chemistry asap (2013). Addison, Bennett; Ashton, Nicholas N.; Weber, Warner; Stewart Russell J.; Holland, Gregory P.; Yarger, Jeffery L., -Sheet Nanocrystalline Domains Formed from Phosphorylated Serine-Rich Motifs in Caddisfly Larval Silk: A Solid State NMR and XRD Study. Biomacromolecules 14(4), 1140-1148 (2013). [DOI: 10.1021/bm400019d] Asakura, Tetsuo; Suzuki, Yu; Nakazawa, Yasumoto; Yazawa, Koji; Holland, Gregory P.; Yarger, Jeffery L., Silk Structure Studied with Nuclear Magnetic Resonance. Progress in Nuclear Magnetic Resonance Spectroscopy 69, 23-68 (2013). [http://dx.doi.org/10.1016/j.pnmrs.2012.08.001] [DOI: 10.1016/j.pnmrs.2012.08.001] Benmore, C.J.; Weber, J.K.R.; Tailor, A.N.; Cherry, B.R.; Yarger, J.L.; Mou, Q.; Weber, W.; Neuefeind, J.; Byrn, S.R., Structural Characterization and Aging of Glassy Pharmaceuticals Made Using Acoustic Levitation. J. Pharmaceutical Sciences 102(4), 1290-1300 (2013). [DOI: 10.1002/jps.23464]