Acosta, E.J. - University of Toronto - Department of Chemical Engineering & Applied Chemistry

个人简介

American Oil Chemists Society American Chemical Society

研究领域

Interfacial Curvature of Surface Active Compounds Surfactant-oil-water systems maybe used as templates to produce nanostructured materials, as delivery vehicles for drugs and food additives, and as solvents in: degreasing, cleaning, bio-separations, polymerization, environmental remediation, and enhanced oil recovery. Formulation of surfactant solutions for these and other applications requires significant experimental work and expertise. From the engineering point of view, most surfactant-based processes are “black boxes” because of the complex thermodynamics of these systems. Current equations of state are just starting to tackle simple systems but are not yet capable of reproducing the phase behavior of complex surfactant-water-oil systems. Recently, a “net-average curvature” model has been proposed to predict the interfacial curvature and physical properties of these complex surfactant-oil-water systems. This project seeks to further develop the net-average curvature model into an “expert system” capable of predicting the properties of surfactant formulations (e.g. solubilization capacity, interfacial tension, droplet size, and viscosity) as a function of surfactant/oil type and composition, electrolyte concentration, temperature, and pressure. Low Surface Tension Films This project will focus on studying the properties and potential applications of low surface tension films consisting of mixtures of negatively-charged (anionic) and positively-charged (cationic) surfactants. This research seeks to gain a fundamental understanding in the thermodynamics of anionic-cationic surfactant films at air/water and air/solid interfaces, and to evaluate the performance of mixed anionic-cationic films in two target areas: hydrophobic coatings, and dewatering agents. Success in these areas could lead to an alternate environmentally safe waterproofing technology and reduction in energy costs in waste treatments facilities. Lecithin-Based Microemulsions as Drug Delivery Vehicles Modern drug delivery vehicles strive to supply drugs on the specific tissues where they are needed, and at a specific rate. Some of the challenges in drug delivery include: the low water solubility of certain drugs, the presence of hydrophilic/hydrophobic zones in living tissues, the metabolism and adsorption of drug and vehicle in other tissues, toxicity associated with the drug and delivery vehicle, the rate of release and others. Drug delivery systems include the use of polymer solutions, surfactant solutions, vesicles, emulsions and microemulsion systems. Microemulsions, in particular, have demonstrated to be excellent vehicles for fast and efficient delivery, but they have the limitation that, in most cases, formulations may contain alcohols and other toxic additives. This work seeks to produce alcohol-free formulations containing phospholipids and sugar-derived bio-compatible surfactants. Drug delivery efficiency and cytotoxicity of these micoemulsions will be evaluated using a transdermal delivery test.

近期论文

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Chu, J., Cheng, Y.-L., Rao, A.V., Nouraei, M., Zarate-Muñoz, S., Acosta, E.J. Lecithin-linker formulations for self-emulsifying delivery of nutraceuticals (2014) International Journal of Pharmaceutics, 471, 92-102. Baxter, M.D., Acosta, E., Montoneri, E., Tabasso, S. Waste biomass-extracted surfactants for heavy oil removal (2014) Industrial and Engineering Chemistry Research, 53, 3612-3621. Wang, Z., Acosta, E. Formulation design for target delivery of iron nanoparticles to TCE zones (2013) Journal of Contaminant Hydrology, 155, 9-19. Troncoso, A.B., Acosta, E. The van der Waals interactions in sphere-shell and cone-shell configurations (2012) Journal of Physical Chemistry B, 116, 14051-14061. Kiran, S.K., Ng, S., Acosta, E.J. Impact of asphaltenes and naphthenic amphiphiles on the phase behavior of solvent-bitumen-water systems (2011) Energy and Fuels, 25, 2223-2231. Saad, S.M.I., Neumann, A.W., Acosta, E.J. A dynamic compression-relaxation model for lung surfactants (2010) Colloids and Surfaces A, 354, 34-44.