Zheng, Jinzi - University of Toronto - Institute of Biomaterials & Biomedical Engineering

个人简介

Scientist, Institute for the Advancement of Technology for Health (TECHNA), University Health Network (UHN) Institute of Biomaterials & Biomedical Engineering

研究领域

Imaging technologies are being increasingly employed to guide the delivery of cancer therapies with the intent to increase their performance and efficacy. To date, many patients have benefited from image-guided treatments through prolonged survival and improvements in quality of life. Our research is focused on the development of agents and tools that can further increase the performance of imaging in the therapy-guidance context. Specifically, we are active in the areas of image-guided surgery, personalized nanomedicine delivery, tracking of cell therapies and high precision radiotherapy delivery.

近期论文

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Lee H, Zheng J, Gaddy D, Orcutt KD, Leonard S, Geretti E, Hesterman J, Harwell C, Hoppin J, Jaffray DA, Wickham T, Hendriks BS, Kirpotin D. A gradient-loadable (64)Cu-chelator for quantifying tumor deposition kinetics of nanoliposomal therapeutics by positron emission tomography. Nanomedicine. 2015 Jan;11(1):155-65. Dou YN, Zheng J, Foltz WD, Weersink R, Chaudary N, Jaffray DA, Allen C. Heat-activated thermosensitive liposomal cisplatin (HTLC) results in effective growth delay of cervical carcinoma in mice. J Control Release. 2014 Mar 28;178:69-78. Zheng J, Boisgard R, Siquier-Pernet K, Decaudin D, Dollé F, Tavitian B. Differential expression of the 18 kDa translocator protein (TSPO) by neoplastic and inflammatory cells in mouse tumors of breast cancer. Mol Pharm. 2011 Jun 6;8(3):823-32. Zheng J, Allen C, Serra S, Vines D, Charron M, Jaffray DA. Liposome contrast agent for CT-based detection and localization of neoplastic and inflammatory lesions in rabbits: validation with FDG-PET and histology. Contrast Media Mol Imaging. 2010 May-Jun;5(3):147-54. Zheng J, Jaffray D, Allen C. Quantitative CT imaging of the spatial and temporal distribution of liposomes in a rabbit tumor model. Mol Pharm. 2009 Mar-Apr;6(2):571-80. Zheng J, Perkins G, Kirilova A, Allen C, Jaffray DA. Multimodal contrast agent for combined computed tomography and magnetic resonance imaging applications. Invest Radiol. 2006 Mar;41(3):339-48.