You, Lidan - University of Toronto - Institute of Biomaterials & Biomedical Engineering

个人简介

Department of Mechanical & Industrial Engineering Institute of Biomaterials & Biomedical Engineering

研究领域

Our research interest is focused on solving biomechanical questions in muscular skeletal system at the cellular level. In specific, we are working on the anti-resorptive effect of mechanical loading on bone tissue; pressure effect on bone cell mechanotransduction; osteogenic potential of high frequency low magnitude vibration on bone adaptation; angiogenesis involvement in initiation of bone resorption under disuse condition; the advanced microfluidic system for bone cell mechanotransduction study; the role of focal adhesion assembly in cell mechanosensitivity using micropatterned surface; and the development of advanced artificial bone matrix by employing novel microfabrication technologies.

近期论文

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“Automated nanomanipulation for nanodevice construction”. Zhang YL, Li J, To S, Zhang Y, Ye X, You L, Sun Y. Nanotechnology. 2012 Jan 17. 23(6). “Osteocyte apoptosis regulate osteoclast precursor adhesion via osteocytic IL-6 secretion and endothelial ICAM-1 expression”. Cheung WY, Simmons CA, You L Bone. 2012 Jan. 50(1):104-10. “Effect of oscillating fluid flow stimulation on osteocyte mRNA expression”. Li J, Rose E, Frances D, Sun Y, You L. J Biomech. 2012 Jan 10;45(2):247-51. “Effect of Nanowire Number, Diameter, and Doping Density on Nano-FET Biosensor Sensitivity”. Li J, Zhang Y, To S, You L, Sun Y. ACS Nano. 2011 Aug 23. 5(8):6661-8. “Apoptotic Osteocytes Regulate Osteoclast Precursor recruitment and differentiation in vitro”. Al-Dujaili SA, Lau E, Al-Dujaili H, Tsang K, Guenther A, You L. J Cell Biochem. 2011 Sep. 112(9):2412-23. “Classification of cell types using a microfluidic device for mechanical and electrical measurement on single cells”. Chen J, Zheng Y, Tan Q, Shojaei-Baghini E, Zhang YL, Li J, Prasad P, You L, Wu XY, Sun Y. Lab Chip. 2011 Sep 21. 11(18):3174-81.