研究领域

Biochemistry

Our research interests focus on the design and assembly of bio-inspired constructs for solar energy conversion, catalysis and signal transduction. The incorporation of artificial antennas and reaction centers into model biological membranes to make solar energized membranes is one of the first steps towards assembling nanoscale devices capable of carrying out human-directed work. It is our sense that the promise and excitement in nanoscale science and technology are predicated on paradigms taken from biology for molecular-scale motors, pumps, signal amplifiers, etc. These devices from biology are powered by proton motive force (pmf) or the thermodynamic equivalent of pmf, ATP. On the other hand, most of the devices we have come to appreciate (and expect) from the human-made world are powered by electromotive force. The membrane potential associated with energized membranes is the common denominator between the energy transducers of biology and their counterparts in the human-made world. Broadly, our research aims to explore this connection and use it to establish links between the systems and thereby determine ways to couple electronic circuits and devices to nanoscale signals and energy transducers. This idea can be elaborated in the field of signal processing/molecular sensors by imagining the design of hybrid devices which link silicon-based elements in an electrical circuit with biological receptors in which molecular recognition provides exquisite specificity at near single molecule sensitivity. In such a device, biological amplifiers (e.g., a G-protein cascade) powered by pmf would provide initial amplification of the signal resulting from the binding of a target ligand by a membrane-linked receptor. The amplified output signal would then be coupled to more conventional circuits for measurement and analysis. In other words, the information/signal at the biological level (ligand recognition and binding) would be amplified using biological amplifiers, the output of which is then translated into an electrical signal for conventional electronic processing. Photosynthetic organisms provide myriad examples of catalysis including several essential redox ones that operate with essentially no over potential. These include the most efficient 4-electron catalyst known for the oxidation of water to yield oxygen and protons. In combination with the biological catalyst for oxygen reduction, found in photosynthetic and all oxygenic organisms, and enzymes for hydrogen production by proton reduction, nature has provided the basic paradigms for fuel cell operation. It is a major goal of our work in artificial photosynthesis to link redox- and pmf-generating constructs to these catalysts in order to enhance our understanding of energy flow in biological systems and to provide energy transduction to meet human needs. Sotomura, T.A. Moore, A.L. Moore and D. Gust,J. Phys. Chem.B 107, 10252-10260 (2003).

近期论文

查看导师新发文章 （温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

"Towards molecular logic and artificial photosynthesis," Gust, D.; Moore, A. L.; Moore, T. A, in Proceedings of the 2007 Solvay Conference on Chemistry Sauvage, J.-P. Ed., Wiley-VCH, in press (2009) "Artificial photosynthesis: Progress and promise," Gust, D.; Moore, A. L.; Moore, T. A, in Ciamician, Profeta dell'Energia Solare Venturi, M. Ed., Fondazione Eni Enrico Mattei, Bologna 187-208 (2009) "Biology and Technology for Photochemical Fuel Production," M. Hambourger, G. F. Moore, D. M. Kramer, D. Gust, A. L. Moore, and T. A. Moore, Chem. Soc. Rev 38 25-35 (2009) "Photoassisted overall water splitting in a visible light-absorbing dye sensitized photoelectrochemical cell," Youngblood, W. J.; Lee, S.-H. A.; Kobayashi, Y.; Hernandez-Pagan, E. A.; Hoertz, P. G.; Moore, T. A.; Moore, A. L.; Gust, D.; Mallouk T. E., J. Am. Chem. Soc. 131 926-929 (2009) "All-Photonic Molecular Keypad Lock," J.; Straight, S. D.; Moore, T. A.; Moore, A. L.; Gust, D., Chem. Eur. J. 15 3936-3939 (2009) "Multiantenna Artificial Photosynthetic Reaction Center Complex," Terazono, Y.; Kodis, G.; Liddell, P. A.; Garg, V.; Moore, T. A.; Moore, A. L.; Gust, D. , J. Phys. Chem. B 113 7147-7155 (2009) "Self-Regulation of Photoinduced Electron Transfer by a Molecular Nonlinear Transducer," S. D. Straight, G. Kodis, Y. Terazono, M. Hambourger, T. A. Moore, A. L. Moore, D. Gust, Nature Nanotechnology 3 280-283 (2008) "Mimicking photosynthesis, but just the best bits," A. W. Rutherford and T. A. Moor, Nature 453 449 (2008) "Entropic changes control the charge separation process in triads mimicking photosynthetic charge separation," Rizzi, A. C.; van Gastel, M.; Liddell, P. A.; Palacios, R. E.; Moore, G. F.; Kodis, G.; Moore, A. L.; Moore, T. A.; Gust, D.; Braslavsky, S. E., J. Phys. Chem. A 112 4215-4223 (2008) "Molecular all-photonic encoder-decoder," Andréasson, J.; Straight, S. D.; Moore, T. A.; Moore, A. L.; Gust, D. J. , J. Am. Chem. Soc. 130 11122-11128 (2008) "Engineered and Artificial Photosynthesis: Human Ingenuity Enters the Game," D. Gust, D. Kramer, A. Moore, T. A. Moore and W. Vermaas, MRS Bulletin 33 383-386 (2008) "A Bioinspired Construct that Mimics the Proton Coupled Electron Transfer between P680+ and the Tyr z-His190 Pair of Photosystem II," G. F. Moore, M. Hambourger, M Gervaldo, O. G. Poluektov, T. Rajh, D. Gust, T. A. Moore and A. L. Moore, J. Am. Chem. Soc. 130 10466-10467 (2008) "Light Harvesting and Photoprotective Functions of Carotenoids in Compact Artificial Photosynthetic Antenna Designs," G. Kodis, C. Herrero, R. Palacios, E. Mari ? o-Ochoa, S. Gould, L. de la Garza, R. van Grondelle, D. Gust, T.A. Moore, A.L. Moore and J.T.M. Kennis, J. Phys. Chem. B 108 414–425 (2004) "Photonic Control of Photoinduced Electron Transfer via Switching of Redox Potentials in a Photochromic Moiety," Y. Terazono, G. Kodis, J. Andréasson, G. Jeong. A. Brune, T. Hartmann, H. Dürr, A.L. Moore, T.A. Moore and D. Gust, J. Phys. Chem 108 1812-1814 (2004) "Photonic Switching of Photoinduced Electron Transfer in a Dihydropyrene-Porphyrin-Fullerene Molecular Triad," P.A. Liddell, G. Kodis, J. Andréasson, L. de la Garza, S. Bandyopadhyay, R.H. Mitchell, T.A. Moore, A.L. Moore and D. Gust, J. Am. Chem. Soc 126 4803-4811 (2004) "Porphyrin-Sensitized Nanoparticulate TiO 2 as the Photoanode of a Hybrid Photoelectrochemical Biofuel Cell," A. Brune, G. Jeong, P.A. Liddell, T. Sotomura, T.A. Moore, A.L. Moore and D. Gust, Langmuir 20 8366-8371 (2004) "Enzyme-Based Photoelectrochemical Biofuel Cell," L. de la Garza, G. Jeong, P.A. Liddell, T. Sotomura, T.A. Moore, A.L. Moore and D. Gust, J. Phys. Chem. B 107 10252-10260 (2003)