Truong, Kien (Kevin) - University of Toronto - Institute of Biomaterials & Biomedical Engineering

个人简介

Edward S. Rogers Sr. Department of Electrical & Computer Engineering Institute of Biomaterials & Biomedical Engineering

研究领域

Cells are continuously processing and reacting to external signals that elicit various responses including cell division, migration, differentiation and death. Decades of research in cell biology has revealed these responses are controlled by cellular signalling pathways that resemble computer networks and electrical circuits. Signalling pathways, however, are composed of a coordinated interaction of proteins mediated by modular domains. Our lab is interested in elucidating the fundamental rules for the engineering of signalling pathways by mutation and recombination of these basic modular domains. Such studies will ultimately improve our understanding of how pathways function and inspire therapies for inhibiting or regulating certain pathways responsible for illness.

近期论文

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Split-intein mediated re-assembly of genetically encoded Ca(2+) indicators. Wong SS, Kotera I, Mills E, Suzuki H, Truong K. Cell Calcium. 2012 Jan. 51(1):57-64. Engineered regulation of lysozyme by the SH3-CB1 binding interaction. Pham E, Truong K. Protein Eng Des Sel. 2012 Jun. 25(6):307-11. Parts-based assembly of synthetic transmembrane proteins in mammalian cells. Nagaraj S, Wong S, Truong K. ACS Synthetic Biology. 2012 Apr 20. 1(4): 111-117. Effects of rapamycin-induced oligomerization of parvalbumin, Stim1 and Orai1 in puncta formation. Pham E, Wong SS, Nagaraj S, Truong K. Cell Calcium. 2012 May. 51(5):418-25. Engineered Networks of Synthetic and Natural Proteins To Control Cell Migration. Evan Mills, Elizabeth Pham, Seema Nagaraj, and Kevin Truong. ACS Synthetic Biology 2012 1 (6), 211-220 Ca2+-mediated synthetic biosystems offer protein design versatility, signal specificity, and pathway rewiring. Mills E, Truong K. Chem Biol. 2011 Dec 23. 18(12):1611-9.