Sone, Eli D. - University of Toronto - Institute of Biomaterials & Biomedical Engineering

个人简介

Institute of Biomaterials & Biomedical Engineering Department of Materials Science & Engineering Additional Appointments Faculty of Dentistry

研究领域

Our work is focused on systems in biology where organic-mineral interactions play a key role. We use a combination of ultrastructural characterization of native tissues and in-vitro investigations of synthetic systems to study the mechanisms of attachment of biological fibres to inorganic substrates. Currently we are working on two systems in which the structure of the interface is critical: adhesion of zebra mussels to rocks, and the attachment of ligaments to bones and teeth. We use a variety of techniques to study these systems; cryo-TEM in particular plays a central role in our work.

近期论文

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PERP regulates enamel formation via effects on cell-cell adhesion and gene expression. Jheon AH, Mostowfi P, Snead ML, Ihrie RA, Sone E, Pramparo T, Attardi LD, Klein OD. J Cell Sci. 2011 Mar 1. 124(Pt 5):745-54. Zebra mussel adhesion: structure of the byssal adhesive apparatus in the freshwater mussel, Dreissena polymorpha. Farsad N, Sone ED. J Struct Biol. 2012 Mar. 177(3):613-20. Bioinspired magnetite mineralization of peptide-amphiphile nanofibers. Eli D. Sone; Samuel I. Stupp (Profiled Author: Samuel Isaac Stupp) Chemistry of Materials. 2011. 23(8):2005-2007. The byssus of the zebra mussel (Dreissena polymorpha): Spatial variations in protein composition. Gilbert TW, Sone ED. Biofouling 2010 26, 829-836. Identification and characterization of aortic valve mesenchymal progenitor cells with robust osteogenic calcification potential. Chen JH, Yip CYY, Sone ED, Simmons CA. American Journal of Pathology. 2009 174, 1109-1119.