Simmons, Craig A. - University of Toronto - Institute of Biomaterials & Biomedical Engineering

个人简介

Department of Mechanical & Industrial Engineering Institute of Biomaterials & Biomedical Engineering Scientific Director, U of T Translational Biology & Engineering Program (TBEP), Ted Rogers Centre for Heart Research Additional Appointments Faculty of Dentistry

研究领域

Cellular mechanobiology, biomechanics, tissue engineering, and biomedical engineering. Approaches integrate experimental and computational cell mechanics with state-of-the-art quantitative cellular and molecular biology. Current applications include stem cell-based tissue engineering; mechanobiological studies of heart valve calcification; and the development of novel technologies for high throughput mechanobiology.

近期论文

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Osteocyte apoptosis regulates osteoclast precursor adhesion via osteocytic IL-6 secretion and endothelial ICAM-1 expression. Cheung WY, Simmons CA, You L. Bone. 2012 Jan. 50(1):104-10. Hydrogel Substrate Stiffness and Topography Interact to Induce Contact Guidance in Cardiac Fibroblasts. Al-Haque S, Miklas JW, Feric N, Chiu LL, Chen WL, Simmons CA, Radisic M. Macromol Biosci. 2012 Oct. 12(10):1342-53. 2012 Aug 27. The elastic properties of valve interstitial cells undergoing pathological differentiation. Wyss K, Yip CY, Mirzaei Z, Jin X, Chen JH, Simmons CA. J Biomech. 2012 Mar 15. 45(5):882-7. A digital microfluidic platform for primary cell culture and analysis. Srigunapalan S, Eydelnant IA, Simmons CA, Wheeler AR. Lab Chip. 2012 Jan 21. 12(2):369-75. An improved texture correlation algorithm to measure substrate-cytoskeletal network strain transfer under large compressive strain. Zhao R, Simmons CA. J Biomech. 2012 Jan 3. 45(1):76-82. Epub 2011 Oct 24. Calcific aortic valve disease: not simply a degenerative process: A review and agenda for research from the National Heart and Lung and Blood Institute Aortic Stenosis Working Group. Executive summary: Calcific aortic valve disease-2011 update. Rajamannan NM, Evans FJ, Aikawa E, Grande-Allen KJ, Demer LL, Heistad DD, Simmons CA, Masters KS, Mathieu P, O’Brien KD, Schoen FJ, Towler DA, Yoganathan AP, Otto CM. Circulation. 2011 Oct 18. 124(16):1783-91.