Radisic, Milica - University of Toronto - Institute of Biomaterials & Biomedical Engineering

个人简介

Institute of Biomaterials & Biomedical Engineering Department of Chemical Engineering & Applied Chemistry

研究领域

Each year nearly 900,000 people in North America alone suffer from myocardial infarction. Tissue engineering may offer alternative treatment options or suitable models for studies of normal and pathological cardiac tissue function in vitro. Conventional tissue engineering approaches are limited by inadequate oxygen supply, lack of physical stimuli and absence of multiple cell types characteristic of the native myocardium. My research program consists of several different projects that all fall under umbrella of cardiac tissue engineering and regenerative medicine. We are focused on pursuing molecular mechanisms governing the formation of contractile cardiac tissue in vitro as well as on practical strategies for treatment of myocardial infarction and heart failure through development of new biomaterials. We pursue the research programs alone (e.g. advanced bioreactors and cell tri-culture) or in collaboration with other PIs (e.g. microfluidic separation of heart cells).

近期论文

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Perfusable branching microvessel bed for vascularization of engineered tissues. Chiu LL, Montgomery M, Liang Y, Liu H, Radisic M. Proc Natl Acad Sci U S A. 2012 Dec 11. 109(50):E3414-23. Hydrogel Substrate Stiffness and Topography Interact to Induce Contact Guidance in Cardiac Fibroblasts. Al-Haque S, Miklas JW, Feric N, Chiu LL, Chen WL, Simmons CA, Radisic M. Macromol Biosci. 2012 Oct. 12(10):1342-53. Controlled delivery of thymosin β4 for tissue engineering and cardiac regenerative medicine. Chiu LL, Reis LA, Radisic M. Ann N Y Acad Sci. 2012 Oct. 1269(1):16-25. Biofabrication enables efficient interrogation and optimization of sequential culture of endothelial cells, fibroblasts and cardiomyocytes for formation of vascular cords in cardiac tissue engineering. Iyer RK, Chiu LL, Vunjak-Novakovic G, Radisic M. Biofabrication. 2012 Sep. 4(3):035002. Generation of tissue constructs for cardiovascular regenerative medicine: From cell procurement to scaffold design. Tandon V, Zhang B, Radisic M, Murthy SK. Biotechnol Adv. 2012 Aug 24. pii: S0734-9750(12)00145-0. Vascular endothelial growth factor secretion by nonmyocytes modulates Connexin-43 levels in cardiac organoids. Tissue Eng Part A. 2012 Sep.18(17-18):1771-83.