研究领域

Biochemistry/Physical Chemistry

Our research is focused on the following three themes: 1. Chemical synthesis and photophysics of quantum materials: Quantum-size semiconductor building blocks, such as quantum dots, quantum wires, and quantum sheets and the corresponding hetero-structures have broad applications ranging from light emitting diodes, nanolasers, nanoelectronics, solar cell devices to biological fluorescent labels. Constructing highly tunable building blocks and the corresponding hetero-structures with control over the size, shape, composition, crystalinity, and their hierarchical structures is vitally important to fully exploit these materials. We aim to develop state of the art colloidal chemistry strategy to synthesize and characterize a series of novel quantum materials with unique optical and electronic properties and investigate their applications in functional nanodevices. 2. Physical chemistry of DNA nanotechnology: DNA nanotechnology allows the design and construction of nanoscale objects that have finely-tuned dimensions, orientation, and structure with remarkable ease and convenience. With the increasing complexity of the DNA nanostructural system these days, much fundamental studies are needed to further understand the underlying physical chemistry. First, we aim to systematically investigate the thermodynamics and kinetics of DNA nanostructure formation. These thermodynamics and kinetics studies will shed light on the stability of the DNA nanostructures, push the limit on their application conditions, and improve their performance. Second, we aim to engineer synthetic DNA nanostructures to model or mimic a variety of other molecules and systems. For example, synthetic DNA nanostructures can be designed to serve as models to study the binding behavior of multi-valent molecules and gain insight into how small changes to the ligand/receptor scaffolds, such as conformational flexibility or relative distance or orientation of the multiple ligands, will affect their association equilibrium with the target molecules. This is important in understanding many multi-valent interactions in nature, like pathogen invasion, immunology recognition, cell-cell interaction. 3. DNA directed deterministic positioning of nanophotonic elements: Systematical study of photonic elements interactions with deterministic positioning at nanometer scale is very important for: a) fundamental understanding of the underlying distance dependent interactions and energy transfer between various photonic elements; b) providing useful models to understand photonic antenna systems existing in nature; c) providing crucial information for constructing artificial biophotonic systems for applications ranging from light harvesting to biosensing. Along this line, we aim to use DNA directed self-assembly to: a) study distance dependent effects between metallic nanoparticles and organic fluorophores; b) construct molecular antenna systems for efficient light harvesting; c) construct and understand geometry dependent energy transfers between fluorophores. We are also collaborating with theory group to fully understand these nanostructured photonic systems. Experiments are designed to test theoretical hypothesis and modeling. New models will be developed by taking into account of many experimental parameters resulting from the deterministic positioning of photonic elements.

近期论文

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"Self-assembly of DNA Rings from Scaffold Free DNA Tiles," Y. Yang, Z. Zhao, F. Zhang, J. Nangreave, Y. Liu*, H. Yan* , Nano letters 13 1862-1866 (2013) "DNA Functionalization of Colloidal II-VI Semiconductor Nanowires," Z. Deng, S. Pal, A. Samanta, H. Yan, Y. Liu*, Chemical Sciences 3 2234-2240 (2013) "Functionalized DNA Nanostructures for Nanomedicine," X. Liu, Y. Liu*, H. Yan*, Israel Journal of Chemistry 53 555–566 (2013) "3-Input Majority Logic Gate and Multiple Input Logic Circuit Based on DNA Strand Displacement," W. Li*, Y. Yang, H. Yan, Y. Liu*, Nano Letters 13 2980-2988 (2013) "Complex Archimedean Tiling Self-assembled from DNA Nanostructures," F. Zhang, Y. Liu*, H. Yan* , J. Am. Chem. Soc. 135 7458-7461 (2013) "Mapping the Thermal Behavior of DNA Origami Nanostructures," X. Wei, J. Nangreave, S. Jiang, H. Yan, Y. Liu*, J. Am. Chem. Soc. 135 6165-6176 (2013) "PNA-peptide Assembly in a 3D DNA Nanocage at Room Temperature," J. Flory, S. Shinde, S. Lin, Y. Liu, H. Yan, G. Ghirlanda, P. Fromme*, J. Am. Chem. Soc. 135 6985-6993 (2013) "Quantum Efficiency Modification of Organic Fluorophores Using Gold Nanoparticles on DNA Origami Scaffolds," S. Pal, P. Dutta, H. Wang, Z. Deng, S. Zou, H. Yan, Y. Liu*, J. Phys. Chem. C 117 12735-12744 (2013) "Tip Induced Fluorescence Quenching for Nanometer Optical and Topographical Resolution, Optical Nanoscopy ," O. Schulz, Z. Zhao, A. Ward, M. Koenig, F. Koberling, Y. Liu, J. Enderlein, H. Yan* and R. Ros*, Optical Nanoscopy 2 1 (2013) "DNA Gridiron Nanostructures Based on Four-Arm Junctions," D. Han*, S. Pal, Y. Yang, S. Jiang, J. Nangreave, Y. Liu*, H. Yan*, Science 339 1412–1415 (2013) "DNA Origami Templated Self-assembly of Discrete Length Single Wall Carbon Nanotubes," Z. Zhao, Y. Liu*, H. Yan*, Org. Biomol. Chem. 11 596–598 (2013) "A DNA Tweezer-Actuated Enzyme Nanoreactor ," M. Liu, J. Fu*, C. Hejesen, Y. Yang, N. W. Woodbury, K. Gothelf, Y. Liu, H. Yan*, Nature Comm. 4 2127 (2013) "Reconfigurable DNA Origami to Generate Quasi-Fractal Patterns," F. Zhang, J. Nangreave, Y. Liu*, H. Yan* , Nano Letters 12 3290–3295 (2012) "Steric Crowding and the Kinetics of DNA Hybridization within a DNA Nanostructure System," A. V. Pinheiro, J. Nangreave, S, Jiang, H. Yan, Y. Liu* , ACS Nano 6 5521–5530 (2012) "Effect of DNA Hairpin Loops on the Twist of Planar DNA Origami Tiles," Z. Li, L. Wang, H. Yan, Y. Liu*, Langmuir 28 1959–1965 (2012) "DNA Origami with Double-Stranded DNA As a Unified Scaffold ," Y. Yang, D. Han, J. Nangreave, , Y. Liu*, H. Yan*, ACS Nano 6 8209–8215 (2012) "A DNA Nanostructure Platform for Directed Assembly of Synthetic Vaccines," X. Liu, Y. Xu, T. Yu, C. Craig, Y. Liu, H. Yan*, Y. Chang*, Nano Letters 12 4254–4259 (2012) "Aqueous Synthesis of Glutathione-Capped CdTe/CdS/ZnS and CdTe/CdSe/ZnS Core/Shell/Shell Nanocrystal Heterostructures," A. Samanta, Z. Deng, Y. Liu*, Langmuir 28 8205–8215 (2012) "Spatially-Interactive Biomolecular Networks Organized by Nucleic Acid Nanostructures," J. Fu, M. Liu, Y. Liu*, H. Yan*, Acc. Chem. Res. 45 1215–1226 (2012) "Robust DNA Functionalized Core/Shell Quantum Dots with Fluorescent Emission Spanning from UV-Vis to Near IR and Compatible with DNA Directed Self-Assembly," Z. Deng, A. Samanta, J. Nangreave, H. Yan*, Y. Liu*, J. Am. Chem. Soc. 134 17424–17427 (2012) "Solution Synthesis of Ultrathin Single-Crystalline SnS Nanoribbons for Photodetectors via Phase Transition and Surface Processing," Z. Deng*, D. Cao, J. He, S. Lin, S. M. Lindsay, Y. Liu* , ACS Nano 6 6197–6207 (2012) "Interenzyme Substrate Diffusion for an Enzyme Cascade Organized on Spatially Addressable DNA Nanostructures," J. Fu, M. Liu, Y. Liu, N. W. Woodbury*, H. Yan* , J. Am. Chem. Soc. 134 5516–5519 (2012) "Size-Selective Incorporation of DNA Nanocages into Nanoporous Antimony-doped Tin Oxide Materials," C. R. Simmons, D. Schmitt, X. Wei, D. Han, A. M. Volosin, D. M Ladd, D. Seo, Y. Liu, H. Yan* , ACS Nano 5 6060–6068 (2011) "Nanomaterials: DNA brings quantum dots to order," Yan Liu, Nature Nanotechnology 6 463-464 (2011) "DNA Origami with Complex Curvatures in 3D Space. ," D. Han*, S. Pal, J. Nangreave, Z. Deng, Y. Liu*, H. Yan*, Science 332 342-344 (2011) "DNA Nanostructures as Models for Evaluating the Role of Enthalpy and Entropy in Polyvalent Binding," J. Nangreave, H. Yan, Y. Liu*, J. Am. Chem. Soc. 133 4490-4497 (2011) "High-Quality Manganese-Doped Zinc Sulfide Quantum Rods with Tunable Dual-Color and Multiphoton Emissions ," Z. Deng. L. Tong, M. Flores, S. Lin, J-X Cheng, H. Yan, Y. Liu*, J. Am. Chem. Soc. 133 5389-5396 (2011) "DNA-Directed Artificial Light-Harvesting Antenna," Palash K. Dutta, Reji Varghese, Jeanette Nangreave, Su Lin, Hao Yan, and Yan Liu , J. Am. Chem. Soc. 133 11985-11993 (2011) "Stability of DNA Origami Nanoarrays in Cell Lysate ," Q. Mei, X. Wei, F. Su, Y. Liu, C. Youngbull, R. Johnson, S. Lindsay, H. Yan*, D. Meldrum*, Nano Letters 11 1477-1482 (2011) "Targeted Cell-Cell Interactions by DNA Nanoscaffold-Templated Multivalent Bi-specific Aptamers," X. Liu, H. Yan, Y. Liu*, Y. Chang* , Small 7 1673–1682 (2011) "Organizing DNA Origami Tiles Into Larger Structures Using Pre-formed Scaffold Frames," Z. Zhao, Y. Liu, H. Yan*, Nano Letters 11 2997–3002 (2011) "DNA Directed Self-Assembly of Anisotropic Plasmonic Nanostructures," S. Pal, Z. Deng, H. Wang, S. Zou, Y. Liu*, H. Yan*, J. Am. Chem. Soc. 133 17606–17609 (2011) "Site specific synthesis and in-situ immobilization of fluorescent silver nanoclusters on DNA nanoscaffolds using Tollens reaction ," Pal, R. Varghese, Z. Deng, H. Yan, Y. Liu*, Angew. Chem. Int. Ed. 50 4176-4179 (2011) "Encapsulation of Gold Nanoparticles in a DNA Origami Cage," Z. Zhao, Y. Liu*, H. Yan* , Angew Chem Int Ed 50 2041-2044 (2011) "Photonic Interactions between Quantum Dots and Au Nanoparticles in DNA Directed Self-assembly ," Q. Wang, H. Wang, C. Lin, J. Sharma, S. Zou, Y. Liu*, Chem. Commun. 240-242 (2010) " A Route to Scale up DNA Origami using DNA Tiles as Folding Staples ," Z. Zhao, H. Yan, Y. Liu*, Angew. Chem. Int. Ed. 49 1414-1417 (2010) "DNA Origami Directed Self-assembly of Discrete Silver Nanoparticle Architectures," S. Pal, Z. Deng, H. Yan and Y. Liu*, Angew. Chem. Int. Ed. 49 2700-2704 (2010) "Aqueous Synthesis of Zinc-Blende CdTe/CdS Magic-Core/Thick-Shell Tetrahedral Shaped Nanocrystals with Near-Infrared Emission ," Z. Deng, O. Schulz, S. Lin, B. Ding, X. Liu, X. Wei, R. Ros, H. Yan, Y. Liu*, J. Am. Chem. Soc. 132 5592-5593 (2010) "Molecular Behavior of DNA Origami in Higher Order Self-assembly, ," Z. Li, M. Liu, L. Wang, H. Yan, Y. Liu*,, J. Am. Chem. Soc. 132 13545-13552 (2010) "Controlled Colloidal Growth of Magic-Sized Ultra-Thin Single-Crystal ZnS Nanowires, ," Z. Deng, H. Yan, Y. Liu*,, Angew. Chem. Int. Ed. 49 8695-8698 (2010) "Designer Nanoarchitectures Self-assembled from Mirror Image DNA. ," C. Lin, Y. Ke, Z. Li, J. Wang, H. Yan* and Y. Liu*, Nano. Lett. 9 433-436 (2009) "Band Gap Engineering of Quaternary Alloyed ZnCdSSe Quantum Dots via a Facile Phosphine-Free Colloidal Method ," Z. Deng, H. Yan, Y. Liu*, J. Am. Chem. Soc. 131 17744-17745 (2009) "Stable Silver Nanoparticle-DNA Conjugates for Directed Self-assembly of Core-Satellite Silver-Gold Nanoclusters," S. Pal, J. Sharma, H. Yan, Y. Liu*, Chem. Commun. 6059-6061 (2009) "Studies of Multivalent DNA Hybridization in a Nanostructured? System. ," J. Nangreave, H. Yan and Y. Liu*, Biophysical J. 97 563-571 (2009) "Distance dependent photoluminescence quenching of molecular dyes with spatially controlled gold nanoparticles. ," R. Chhabra, J. Sharma, S. Zou, S. Lin, H. Yan S. Lindsay*, Y. Liu*., Nanotechnology 20 485201 (2009) "Towards Reliable Gold Naoparticles Patterning in Self-assembled DNA nanoscaffold," J. Sharma, R. Chhabra, C. S. Andersen, K. V. Gothelf, H. Yan and Y. Liu*, J. Am. Chem. Soc. 130 7820-7821 (2008) "A Facile In situ Generation of Dithiocarbamate Ligands for Stable Gold Nanoparticle-Oligonucleotide Conjugates," J. Sharma, R. Chhabra, H. Yan and Y. Liu*, Chem. Commun. 2140-2142 (2008) "Subtractive assembly of DNA nanoarchitectures driven by fuel strand displacement," Zhe Li, Yonggang Ke, Chenxiang Lin, Hao Yan and Yan Liu*, Chem. Commun. 4318-4320 (2008) "pH-driven Conformational Switch of i-motif DNA for Reversible Assembly of Gold Nanoparticles," J. Sharma, R. Chhabra, H. Yan, Y. Liu*, Chem. Commum. 477-479 (2006)