个人简介

Ph.D. Hokkaido University 1994 M.Sc. Hokkaido University 1991 B.A. Hokkaido University 1989

研究领域

Biotechnology Cell Biology Functional Genomics Genetics Molecular Biology Plant Biology Structural Biology Systems Biology

Understanding the molecular mechanism of plant defense systems is critical in determining how plants defend themselves against various stresses, including pathogens and applying this knowledge to improve agricultural production and protect environment against possible negative impact from pesticides and fungicides. The long-term goal of my laboratory is to understand how plants transmit the intra- and inter-cellular signals of various environmental stresses including pathogen infection. To achieve this goal, we are using both forward and reverse genetics approaches to identifying novel components (genes/proteins) that are involved in plant immunity. One group of genes that we have identified are cyclic nucleotide-gated ion channels (CNGCs). They form a large gene family and affect multiple aspects of plant physiology such as pollen development, thermal sensing and immunity, likely through Ca2+ signaling. Using molecular, genetic and biochemical analyses, we are investigating the molecular basis of CNGCs. Other aspects we focus on are environmental effects on plant immunity. It has been known that environmental condition such as temperature and humidity significantly affect the activation of defense responses. This suggests that plants possess an elaborate signaling network to fine-tune the responses against multiple stresses. We investigate the signal crosstalk between abiotic and biotic stress signal transduction to understand the complexity of the signaling network and apply this knowledge for developing novel technology to protect plants and environment.

近期论文

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Multiple Calmodulin-Binding Sites Positively and Negatively Regulate Arabidopsis CYCLIC NUCLEOTIDE-GATED CHANNEL12. DeFalco, Thomas A, Christopher B Marshall, Kim Munro, Hong-Gu Kang, Wolfgang Moeder, Mitsuhiko Ikura, Wayne A Snedden, and Keiko Yoshioka. The Plant cell, no. 7 ( 22). 2016 doi:10.1105/tpc.15.00870 pubmed Opening the Gates: Insights into Cyclic Nucleotide-Gated Channel-Mediated Signaling Wolfgang Moeder, and Keiko Yoshioka. Trends in plant science ( 9). 1016 doi:S1360-1385(16)30122-4. pubmed Arabidopsis triphosphate tunnel metalloenzyme2 is a negative regulator of the salicylic Acid-mediated feedback amplification loop for defense responses.Ung H, Moeder W, Yoshioka K.Plant Physiol. 2014 Oct;166(2):1009-21 pubmed The Arabidopsis cyclic nucleotide-gated ion channels AtCNGC2 and AtCNGC4 work in the same signaling pathway to regulate pathogen defense and floral transition.Chin K, DeFalco TA, Moeder W, Yoshioka K.Plant Physiol. 2013 Oct;163(2):611-24 pubmed Crystal structure and biochemical analyses reveal that the Arabidopsis triphosphate tunnel metalloenzyme AtTTM3 is a tripolyphosphatase involved in root development.Moeder W, Garcia-Petit C, Ung H, Fucile G, Samuel MA, Christendat D, Yoshioka K.Plant J. 2013 Nov;76(4):615-26 pubmed A suppressor screen of the chimeric AtCNGC11/12 reveals residues important for intersubunit interactions of cyclic nucleotide-gated ion channels.Abdel-Hamid H, Chin K, Moeder W, Shahinas D, Gupta D, Yoshioka K.Plant Physiol. 2013 Jul;162(3):1681-93 pubmed High throughput chemical screening supports the involvement of Ca2+ in cyclic nucleotide-gated ion channel-mediated programmed cell death in Arabidopsis.Abdel-Hamid H, Chin K, Moeder W, Yoshioka K.Plant Signal Behav 2011 Nov;6(11):1817-9 pubmed Altered germination and subcellular localization patterns for PUB44/SAUL1 in response to stress and phytohormone treatments.Salt JN, Yoshioka K, Moeder W, Goring DR.PLoS ONE 2011;6(6):e21321 pubmed The role of cyclic nucleotide-gated ion channels in plant immunity.Moeder W, Urquhart W, Ung H, Yoshioka K.Mol Plant 2011 May;4(3):442-52 pubmed The cyclic nucleotide-gated channels AtCNGC11 and 12 are involved in multiple Ca²⁺-dependent physiological responses and act in a synergistic manner.Urquhart W, Chin K, Ung H, Moeder W, Yoshioka K.J. Exp. Bot. 2011 Jun;62(10):3671-82 pubmed The roles of ABA in plant-pathogen interactions.Cao FY, Yoshioka K, Desveaux D.J. Plant Res. 2011 Jul;124(4):489-99 pubmed