个人简介

Ph.D. University of Tubingen, Germany 1983 M.Sc. University of Tubingen 1979

研究领域

Cell Biology Developmental Biology Quantitative Biology

Gastrulation is the first major morphogenetic event in animal development, which establishes the basic body plan of the organism. We study the cellular basis and the molecular control of gastrulation processes such as cell migration, cell rearrangement, and tissue boundary formation, using the Xenopus embryo as a model system. Molecularly, we focus on the role of cadherin-mediated adhesion, Eph receptor/ephrin ligand signalling, and non-canonical Wnt signalling in boundary formation and cell rearrangement, and on PDGF- and non-canonical Wnt signalling in cell migration. We also explore the mechanical properties of gastrula tissues, which determine the forces generated in the embryo, embryo structure, and the rate of tissue shape changes. For example, important mechanical parameters are tissue surface tension and tissue viscosity, and we developed methods to measure these in the Xenopus embryo, to see how they are correlated with gastrulation movements and controlled by molecular mechanisms such as Eph signalling. Altogether, our studies shed light not only on the fundamental process of gastrulation, but help to clarify basic general processes such as boundary formation and cell movement.

近期论文

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PAPC mediates self/non-self-distinction during Snail1-dependent tissue separation.Luu O, Damm EW, Parent SE, Barua D, Smith TH, Wen JW, Lepage SE, Nagel M, Ibrahim-Gawel H, Huang Y, Bruce AE, Winklbauer R.J. Cell Biol. 2015 Mar;208(6):839-856 pubmed Ephrin-Eph signaling in embryonic tissue separation.Fagotto F, Winklbauer R, Rohani N.Cell Adh Migr 2014;8(4):308-26 pubmed Tissue cohesion and the mechanics of cell rearrangement.David R, Luu O, Damm EW, Wen JW, Nagel M, Winklbauer R.Development 2014 Oct;141(19):3672-82 pubmed Variable combinations of specific ephrin ligand/Eph receptor pairs control embryonic tissue separation.Rohani N, Parmeggiani A, Winklbauer R, Fagotto F.PLoS Biol. 2014 Sep;12(9):e1001955 pubmed EphA4-dependent Brachyury expression is required for dorsal mesoderm involution in the Xenopus gastrula.Evren S, Wen JW, Luu O, Damm EW, Nagel M, Winklbauer R.Development 2014 Oct;141(19):3649-61 pubmed Internalizing the vegetal cell mass before and during amphibian gastrulation: vegetal rotation and related movements.Winklbauer R, Damm EW.Wiley Interdiscip Rev Dev Biol 2012 Mar-Apr;1(2):301-6 pubmed Cadherin function during Xenopus gastrulation.Winklbauer R.Subcell. Biochem. 2012;60:301-20 pubmed Cadherin-dependent differential cell adhesion in Xenopus causes cell sorting in vitro but not in the embryo.Ninomiya H, David R, Damm EW, Fagotto F, Niessen CM, Winklbauer R.J. Cell. Sci. 2012 Apr;125(Pt 8):1877-83 pubmed Mink1 regulates β-catenin-independent Wnt signaling via Prickle phosphorylation.Daulat AM, Luu O, Sing A, Zhang L, Wrana JL, McNeill H, Winklbauer R, Angers S.Mol. Cell. Biol. 2012 Jan;32(1):173-85 pubmed Mesoderm layer formation in Xenopus and Drosophila gastrulation.Winklbauer R, Müller HA.Phys Biol 2011 Aug;8(4):045001 pubmed EphrinB/EphB signaling controls embryonic germ layer separation by contact-induced cell detachment.Rohani N, Canty L, Luu O, Fagotto F, Winklbauer R.PLoS Biol. 2011 Mar;9(3):e1000597 pubmed Knockdown of SPARC leads to decreased cell-cell adhesion and lens cataracts during post-gastrula development in Xenopus laevis.Huynh MH, Zhu SJ, Kollara A, Brown T, Winklbauer R, Ringuette M.Dev. Genes Evol. 2011 Mar;220(11-12):315-27 pubmed