个人简介

Ph.D. University of Toronto 2000 B.Sc. McMaster University 1994

研究领域

Cell Biology Developmental Biology Functional Genomics Genetics Molecular Biology Neurobiology

The production of nerve cells (neurogenesis) is a life-long process with regional specialization that is critical for the formation of distinct functional domains in the vertebrate nervous system. Moreover, neurogenesis in the mature nervous system may contribute to the structural changes that underlie neural plasticity, which is crucial for sensory processing and behaviour. My lab investigates how neurogenesis contributes to the generation and maintenance of regional nerve cell diversity throughout life. We utilize various molecular genetic techniques in order to identify and characterize the molecular mechanisms that govern vertebrate neurogenesis.

近期论文

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Changes in the social environment induce neurogenic plasticity predominantly in niches residing in sensory structures of the zebrafish brain independently of cortisol levels.Lindsey BW, Tropepe V.Dev Neurobiol 2014 Apr; pubmed Casting a wider fish net on animal models in neuropsychiatric research.Hall ZJ, De Serrano AR, Rodd FH, Tropepe V.Prog. Neuropsychopharmacol. Biol. Psychiatry 2014 Apr; pubmed Cockayne syndrome b maintains neural precursor function.Sacco R, Tamblyn L, Rajakulendran N, Bralha FN, Tropepe V, Laposa RR.DNA Repair (Amst.) 2013 Feb;12(2):110-20 pubmed Toll-like signaling and the cytokine IL-6 regulate histone deacetylase dependent neuronal survival.Forgione N, Tropepe V.PLoS ONE 2012;7(7):e41033 pubmed Zfhx1b induces a definitive neural stem cell fate in mouse embryonic stem cells.Dang LT, Wong L, Tropepe V.Stem Cells Dev. 2012 Oct;21(15):2838-51 pubmed The ontogeny of somatic stem cells.Tropepe V, Turksen K.Stem Cell Rev 2012 Jun;8(2):548-50 pubmed The cellular composition of neurogenic periventricular zones in the adult zebrafish forebrain.Lindsey BW, Darabie A, Tropepe V.J. Comp. Neurol. 2012 Jul;520(10):2275-316 pubmed Histone deacetylase inhibition promotes Caspase-independent cell death of ventral midbrain neurons.Forgione N, Tropepe V.Mol. Cell. Neurosci. 2011 Oct;48(2):117-28 pubmed The role of dopaminergic signalling during larval zebrafish brain development: a tool for investigating the developmental basis of neuropsychiatric disorders.Souza BR, Tropepe V.Rev Neurosci 2011;22(1):107-19 pubmed Dopamine D2 receptor activity modulates Akt signaling and alters GABAergic neuron development and motor behavior in zebrafish larvae.Souza BR, Romano-Silva MA, Tropepe V.J. Neurosci. 2011 Apr;31(14):5512-25 pubmed The PI3K/Akt/mTOR pathway mediates retinal progenitor cell survival under hypoxic and superoxide stress.Sanghera KP, Mathalone N, Baigi R, Panov E, Wang D, Zhao X, Hsu H, Wang H, Tropepe V, Ward M, Boyd SR.Mol. Cell. Neurosci. 2011 Jun;47(2):145-53 pubmed