个人简介

Ph.D. Imperial College London 2006 B.Sc.. University of Calgary 2001

研究领域

Cell Biology

Over the last decade the ability to resolve biochemical events within individual cells has transformed our view of intracellular signalling and provided vital spatio-temporal information about the activation of cell surface receptors. What has emerged is that the organization and dynamics of cell surface receptors plays a critical role in directing cell signalling and effector cell fate. My research focuses on the molecular mechanisms controlling the organization and dynamics of immune cell receptors and the functional significance for immune cell activation using cutting edge optical microscopy to visualize individual molecules and macromolecular clusters of cell surface proteins in single cells. My current research investigates the potential for extracellular regulatory mechanisms for receptor organization, such as glycan-based domains generated by the binding of galectins to cell surface glycoproteins. The galectins are a family of lectins that can bind b-galactoside on cell surface glycoproteins to form an extracellular molecular lattice. My laboratory uses advanced optical microscopy techniques to explore how these cell-surface scaffolding proteins could modulate the interaction, function and turnover of immune cell glycoproteins.

近期论文

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The actin and tetraspanin networks organize receptor nanoclusters to regulate B cell receptor-mediated signaling.Mattila PK, Feest C, Depoil D, Treanor B, Montaner B, Otipoby KL, Carter R, Justement LB, Bruckbauer A, Batista FD.Immunity 2013 Mar;38(3):461-74 pubmed B-cell receptor: from resting state to activate.Treanor B.Immunology 2012 May;136(1):21-7 pubmed Editorial: Counting the carbs: a memory B cell makeover.Treanor B, Cancro MP.J. Leukoc. Biol. 2011 Jul;90(1):1-3 pubmed Dynamic cortical actin remodeling by ERM proteins controls BCR microcluster organization and integrity.Treanor B, Depoil D, Bruckbauer A, Batista FD.J. Exp. Med. 2011 May;208(5):1055-68 pubmed Visualizing a role for the actin cytoskeleton in the regulation of B-cell activation.Batista FD, Treanor B, Harwood NE.Immunol. Rev. 2010 Sep;237(1):191-204 pubmed Organisation and dynamics of antigen receptors: implications for lymphocyte signalling.Treanor B, Batista FD.Curr. Opin. Immunol. 2010 Jun;22(3):299-307 pubmed The membrane skeleton controls diffusion dynamics and signaling through the B cell receptor.Treanor B, Depoil D, Gonzalez-Granja A, Barral P, Weber M, Dushek O, Bruckbauer A, Batista FD.Immunity 2010 Feb;32(2):187-99 pubmed Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production.Randall KL, Lambe T, Johnson AL, Johnson A, Treanor B, Kucharska E, Domaschenz H, Whittle B, Tze LE, Enders A, Crockford TL, Bouriez-Jones T, Alston D, Cyster JG, Lenardo MJ, Mackay F, Deenick EK, Tangye SG, Chan TD, Camidge T, Brink R, Vinuesa CG, Batista FD, Cornall RJ, Goodnow CC.Nat. Immunol. 2009 Dec;10(12):1283-91 pubmed Microsignalosomes: spatially resolved receptor signalling.Treanor B, Harwood NE, Batista FD.Biochem. Soc. Trans. 2009 Oct;37(Pt 5):1014-8 pubmed Early events of B cell activation by antigen.Depoil D, Weber M, Treanor B, Fleire SJ, Carrasco YR, Harwood NE, Batista FD.Sci Signal 2009;2(63):pt1 pubmed