个人简介

University of Oregon PhD in Biology 2007 Hamilton College BA in Biology 1999

研究领域

Neurobiology Psychology & Behavior Systems Biology

Essential to our daily lives is the ability to use sensory information to plan and produce goal-directed movements. There is an incredible amount of complexity in the sensorimotor circuits that control even the most basic of behaviours such as reaching for an object. The focus of my laboratory is to understand the structure and function of sensorimotor circuits at the level of individual neurons and their associated neural circuits using the larval zebrafish as a model system. The zebrafish is a powerful model to study neural circuits due to its unparalleled combination of experimental approaches, notably the ability to optically monitor and manipulate activity throughout the brain. We utilize two-photon calcium imaging, optogenetic manipulation of neural activity, neuroanatomical tracing and quantitative behavioural analysis to determine how circuits in the fish transform visual information into goal-directed movements. Given the strong conservation of brain organization across vertebrates, discoveries made in zebrafish can provide core insights into the function of similar circuits in mammals.

近期论文

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A dedicated visual pathway for prey detection in larval zebrafish.Semmelhack JL, Donovan JC, Thiele TR, Kuehn E, Laurell E, Baier H.Elife 2014;3 pubmed Descending control of swim posture by a midbrain nucleus in zebrafish.Thiele TR, Donovan JC, Baier H.Neuron 2014 Aug;83(3):679-91 pubmed An image-free opto-mechanical system for creating virtual environments and imaging neuronal activity in freely moving Caenorhabditis elegans.Faumont S, Rondeau G, Thiele TR, Lawton KJ, McCormick KE, Sottile M, Griesbeck O, Heckscher ES, Roberts WM, Doe CQ, Lockery SR.PLoS ONE 2011;6(9):e24666 pubmed Optogenetic analysis of synaptic transmission in the central nervous system of the nematode Caenorhabditis elegans.Lindsay TH, Thiele TR, Lockery SR.Nat Commun 2011;2:306 pubmed The neural network for chemotaxis to tastants in Caenorhabditis elegans is specialized for temporal differentiation.Thiele TR, Faumont S, Lockery SR.J. Neurosci. 2009 Sep;29(38):11904-11 pubmed Functional asymmetry in Caenorhabditis elegans taste neurons and its computational role in chemotaxis.Suzuki H, Thiele TR, Faumont S, Ezcurra M, Lockery SR, Schafer WR.Nature 2008 Jul;454(7200):114-7 pubmed Artificial dirt: microfluidic substrates for nematode neurobiology and behavior.Lockery SR, Lawton KJ, Doll JC, Faumont S, Coulthard SM, Thiele TR, Chronis N, McCormick KE, Goodman MB, Pruitt BL.J. Neurophysiol. 2008 Jun;99(6):3136-43 pubmed Step-response analysis of chemotaxis in Caenorhabditis elegans.Miller AC, Thiele TR, Faumont S, Moravec ML, Lockery SR.J. Neurosci. 2005 Mar;25(13):3369-78 pubmed Natural variation in the npr-1 gene modifies ethanol responses of wild strains of C. elegans.Davies AG, Bettinger JC, Thiele TR, Judy ME, McIntire SL.Neuron 2004 Jun;42(5):731-43 pubmed A central role of the BK potassium channel in behavioral responses to ethanol in C. elegans.Davies AG, Pierce-Shimomura JT, Kim H, VanHoven MK, Thiele TR, Bonci A, Bargmann CI, McIntire SL.Cell 2003 Dec;115(6):655-66 pubmed