个人简介

Ph.D. Weizmann Institute of Science 2003 B.Sc. University of Buenos Aires 1998

研究领域

Biotechnology Cell Biology Evolutionary Biology Synthetic Biology Systems Biology

Our research focuses on the following specific areas: 1. Evolution of Signaling Networks Signaling networks’ functions are altered by genetic change. Some changes may lead to adaptive evolution. We are investigating how mutations, such as gene duplication, recombination, or amino acid substitutions, affect the function of signaling networks. 2. Signaling Network Malfunction and Disease While some mutations are beneficial, many others are detrimental, sometimes leading to disease. For instance, cancer often arises from mutations in signaling pathways that control cell growth. We are developing high-throughput model systems to investigate the relationship between signaling network malfunction and disease. 3. Synthetic Biology of Signaling Networks The ability to precisely control the function of signaling networks will open the door to endless biotechnological applications, including cell-based therapies, biosensors or microbiological platforms for the production of biochemicals and biofuels. We are developing synthetic biology methods based on the unique bioengineering abilities of evolution.

近期论文

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Current approaches in evolution: From molecules to cells and organisms.Thattai M, Peisajovich SG.J. Exp. Zool. B Mol. Dev. Evol. 2014 Jul; pubmed The role of domain shuffling in the evolution of signaling networks.Di Roberto RB, Peisajovich SG.J. Exp. Zool. B Mol. Dev. Evol. 2014 Feb;322(2):65-72 pubmed Evolutionary synthetic biology.Peisajovich SG.ACS Synth Biol 2012 Jun;1(6):199-210 pubmed Bacterial virulence proteins as tools to rewire kinase pathways in yeast and immune cells.Wei P, Wong WW, Park JS, Corcoran EE, Peisajovich SG, Onuffer JJ, Weiss A, Lim WA.Nature 2012 Aug;488(7411):384-8 pubmed Rapid diversification of cell signaling phenotypes by modular domain recombination.Peisajovich SG, Garbarino JE, Wei P, Lim WA.Science 2010 Apr;328(5976):368-72 pubmed Rewiring cells: synthetic biology as a tool to interrogate the organizational principles of living systems.Bashor CJ, Horwitz AA, Peisajovich SG, Lim WA.Annu Rev Biophys 2010;39:515-37 pubmed Protein engineers turned evolutionists.Peisajovich SG, Tawfik DS.Nat. Methods 2007 Dec;4(12):991-4 pubmed Amplification of complex gene libraries by emulsion PCR.Williams R, Peisajovich SG, Miller OJ, Magdassi S, Tawfik DS, Griffiths AD.Nat. Methods 2006 Jul;3(7):545-50 pubmed Evolution of new protein topologies through multistep gene rearrangements.Peisajovich SG, Rockah L, Tawfik DS.Nat. Genet. 2006 Feb;38(2):168-74 pubmed Liposomes in identification and characterization of viral fusogenic peptides.Peisajovich SG, Shai Y.Meth. Enzymol. 2003;372:361-73 pubmed Viral fusion proteins: multiple regions contribute to membrane fusion.Peisajovich SG, Shai Y.Biochim. Biophys. Acta 2003 Jul;1614(1):122-9 pubmed C-terminal octylation rescues an inactive T20 mutant: implications for the mechanism of HIV/SIMIAN immunodeficiency virus-induced membrane fusion.Peisajovich SG, Gallo SA, Blumenthal R, Shai Y.J. Biol. Chem. 2003 Jun;278(23):21012-7 pubmed