个人简介

MSc, University of Calgary, 1984 Bsc, McGill University, 1981

研究领域

Bioinformatics & Computational Biology Comparative Genomics Developmental Biology Functional Genomics

The technology required for cancer research has become increasingly more complex over the past several years. Accordingly, the development of innovative solutions to handle the large and complicated datasets these new technologies generate has become an essential part of the cancer research process. OICR’s Informatics and Bio-computing Program integrates and interprets these data, and develops visualization tools to turn this raw data into meaningful information for biologists, clinicians and trainees. The Ouellette group is involved in many aspects of this process, and in particular with respect to RNA-Seq data analysis, where we try to identify the best tools and methods for the functional genomic interpretation of this data. Ouellette is also the Scientific Coordinator of the Canadian Bioinformatics Workshop series that offers a number of short bioinformatics workshops throughout Canada, and throughout the year (see bioinformatics.ca for details).

近期论文

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The International Cancer Genome Consortium's evolving data-protection policies.Milius D, Dove ES, Chalmers D, Dyke SO, Kato K, Nicolás P, Ouellette BF, Ozenberger B, Rodriguez LL, Zeps N, Joly Y.Nat. Biotechnol. 2014 Jun;32(6):519-23 pubmed Education in computational biology today and tomorrow.Fox JA, Ouellette BF.PLoS Comput. Biol. 2013 Dec;9(12):e1003391 pubmed Computational approaches to identify functional genetic variants in cancer genomes.Gonzalez-Perez A, Mustonen V, Reva B, Ritchie GR, Creixell P, Karchin R, Vazquez M, Fink JL, Kassahn KS, Pearson JV, Bader GD, Boutros PC, Muthuswamy L, Ouellette BF, Reimand J, Linding R, Shibata T, Valencia A, Butler A, Dronov S, Flicek P, Shannon NB, Carter H, Ding L, Sander C, Stuart JM, Stein LD, Lopez-Bigas N, .Nat. Methods 2013 Aug;10(8):723-9 pubmed Compensating for literature annotation bias when predicting novel drug-disease relationships through Medical Subject Heading Over-representation Profile (MeSHOP) similarity.Cheung WA, Ouellette BF, Wasserman WW.BMC Med Genomics 2013;6 Suppl 2:S3 pubmed Navigating the changing learning landscape: perspective from bioinformatics.ca.Brazas MD, Ouellette BF.Brief. Bioinformatics 2013 Sep;14(5):556-62 pubmed Inferring novel gene-disease associations using Medical Subject Heading Over-representation Profiles.Cheung WA, Ouellette BF, Wasserman WW.Genome Med 2012;4(9):75 pubmed Quantitative biomedical annotation using medical subject heading over-representation profiles (MeSHOPs).Cheung WA, Ouellette BF, Wasserman WW.BMC Bioinformatics 2012;13:249 pubmed A decade of Web Server updates at the Bioinformatics Links Directory: 2003-2012.Brazas MD, Yim D, Yeung W, Ouellette BF.Nucleic Acids Res. 2012 Jul;40(Web Server issue):W3-W12 pubmed The 2011 Bioinformatics Links Directory update: more resources, tools and databases and features to empower the bioinformatics community.Brazas MD, Yim DS, Yamada JT, Ouellette BF.Nucleic Acids Res. 2011 Jul;39(Web Server issue):W3-7 pubmed CAERUS: predicting CAncER oUtcomeS using relationship between protein structural information, protein networks, gene expression data, and mutation data.Zhang KX, Ouellette BF.PLoS Comput. Biol. 2011 Mar;7(3):e1001114 pubmed Genome variation in Cryptococcus gattii, an emerging pathogen of immunocompetent hosts.D'Souza CA, Kronstad JW, Taylor G, Warren R, Yuen M, Hu G, Jung WH, Sham A, Kidd SE, Tangen K, Lee N, Zeilmaker T, Sawkins J, McVicker G, Shah S, Gnerre S, Griggs A, Zeng Q, Bartlett K, Li W, Wang X, Heitman J, Stajich JE, Fraser JA, Meyer W, Carter D, Schein J, Krzywinski M, Kwon-Chung KJ, Varma A, Wang J, Brunham R, Fyfe M, Ouellette BF, Siddiqui A, Marra M, Jones S, Holt R, Birren BW, Galagan JE, Cuomo CA.MBio 2011;2(1):e00342-10 pubmed Towards BioDBcore: a community-defined information specification for biological databases.Gaudet P, Bairoch A, Field D, Sansone SA, Taylor C, Attwood TK, Bateman A, Blake JA, Bult CJ, Cherry JM, Chisholm RL, Cochrane G, Cook CE, Eppig JT, Galperin MY, Gentleman R, Goble CA, Gojobori T, Hancock JM, Howe DG, Imanishi T, Kelso J, Landsman D, Lewis SE, Karsch Mizrachi I, Orchard S, Ouellette BF, Ranganathan S, Richardson L, Rocca-Serra P, Schofield PN, Smedley D, Southan C, Tan TW, Tatusova T, Whetzel PL, White O, Yamasaki C, .Database (Oxford) 2011;2011:baq027 pubmed