个人简介

Ph.D. University of Colorado 2004

研究领域

Bioinformatics Biotechnology Molecular Biology Quantitative Biology

My research focuses on studying the conformational dynamics of DNA, which, while being intimately involved in genetic function, has operational effects that are not well understood at present. Errors in genetic expression, besides arising from mistakes in the code itself, could also manifest by macromolecules that over-twist or over-stretch the DNA, problems in packing within the nucleus, long-range interference between genes, and so on. Studying the dynamics of DNA, while challenging, has the potential to define a new paradigm for our understanding of cellular function, which could have a range of implications for our understanding of health and disease.

近期论文

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1: Singh K, Milstein JN, Navarre WW. Xenogeneic Silencing and Its Impact on Bacterial Genomes. Annu Rev Microbiol. 2016 Jun 17. [Epub ahead of print] PubMed PMID: 27359215. 2: Mazouchi A, Milstein JN. Fast Optimized Cluster Algorithm for Localizations (FOCAL): a spatial cluster analysis for super-resolved microscopy. Bioinformatics. 2016 Mar 1;32(5):747-54. doi: 10.1093/bioinformatics/btv630. Epub 2015 Nov 4. PubMed PMID: 26543172. 3: Pollari R, Milstein JN. Improved axial trapping with holographic optical tweezers. Opt Express. 2015 Nov 2;23(22):28857-67. doi: 10.1364/OE.23.028857. PubMed PMID: 26561154. 4: Wang H, Milstein JN. Simulation Assisted Analysis of the Intrinsic Stiffness for Short DNA Molecules Imaged with Scanning Atomic Force Microscopy. PLoS One. 2015 Nov 4;10(11):e0142277. doi: 10.1371/journal.pone.0142277. eCollection 2015. PubMed PMID: 26535902; PubMed Central PMCID: PMC4633100. 5: Yehoshua S, Pollari R, Milstein JN. Axial Optical Traps: A New Direction for Optical Tweezers. Biophys J. 2015 Jun 16;108(12):2759-66. doi: 10.1016/j.bpj.2015.05.014. Review. PubMed PMID: 26083913; PubMed Central PMCID: PMC4472083. 6: Wang H, Yehoshua S, Ali SS, Navarre WW, Milstein JN. A biomechanical mechanism for initiating DNA packaging. Nucleic Acids Res. 2014 Oct 29;42(19):11921-7. doi: 10.1093/nar/gku896. Epub 2014 Oct 1. PubMed PMID: 25274732; PubMed Central PMCID: PMC4231757.