个人简介

Ph.D. Duke University B.Sc. Concordia University

研究领域

Animal Biology Bioinformatics & Computational Biology Functional Genomics Genetics Neurobiology Physiology Psychology & Behavior Systems Biology

We use techniques in molecular biology, behavioural neuroscience, and functional genomics to study phenotype. A major focus of the lab is the role of epigenetic mechanisms that confer inter-individual variation in glucocorticoid signaling pathways. Social factors, infections, toxins and disease can all influence gluccorticoid signaling. As such, glucocorticoid signaling pathways act as sensors for environmental signals that affect a range of physiological functions from the response to stress to inflammation. Another major focus in the lab is the role of early life environmental adversity in altering brain and behaviour later in life via epigenetic mechanisms. We study a variety of organisms, from animals in the lab to wild populations and humans.

近期论文

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DNA Methylation Modifications Associated with Chronic Fatigue Syndrome.de Vega WC, Vernon SD, McGowan PO.PLoS ONE 2014;9(8):e104757 pubmed Cocaine exposure prior to pregnancy alters the psychomotor response to cocaine and transcriptional regulation of the dopamine D1 receptor in adult male offspring.Sasaki A, Constantinof A, Pan P, Kupferschmidt DA, McGowan PO, Erb S.Behav. Brain Res. 2014 May;265:163-70 pubmed Epigenomic Mechanisms of Early Adversity and HPA Dysfunction: Considerations for PTSD Research.McGowan PO.Front Psychiatry 2013;4:110 pubmed Biological embedding in mental health: an epigenomic perspective.Sasaki A, de Vega WC, McGowan PO.Biochem. Cell Biol. 2013 Feb;91(1):14-21 pubmed Conserved epigenetic sensitivity to early life experience in the rat and human hippocampus.Suderman M, McGowan PO, Sasaki A, Huang TC, Hallett MT, Meaney MJ, Turecki G, Szyf M.Proc. Natl. Acad. Sci. U.S.A. 2012 Oct;109 Suppl 2:17266-72 pubmed Epigenetic clues to the biological embedding of early life adversity.McGowan PO.Biol. Psychiatry 2012 Jul;72(1):4-5 pubmed Broad epigenetic signature of maternal care in the brain of adult rats.McGowan PO, Suderman M, Sasaki A, Huang TC, Hallett M, Meaney MJ, Szyf M.PLoS ONE 2011;6(2):e14739 pubmed Impaired social recognition memory in recombination activating gene 1-deficient mice.McGowan PO, Hope TA, Meck WH, Kelsoe G, Williams CL.Brain Res. 2011 Apr;1383:187-95 pubmed The Neurological Ecology of Fear: Insights Neuroscientists and Ecologists Have to Offer one Another.Clinchy M, Schulkin J, Zanette LY, Sheriff MJ, McGowan PO, Boonstra R.Front Behav Neurosci 2010;4:21 pubmed Environmental epigenomics: understanding the effects of parental care on the epigenome.McGowan PO, Szyf M.Essays Biochem. 2010 Sep;48(1):275-87 pubmed The epigenetics of social adversity in early life: implications for mental health outcomes.McGowan PO, Szyf M.Neurobiol. Dis. 2010 Jul;39(1):66-72 pubmed