个人简介

Ph.D., University of Toronto, 2009

研究领域

Animal Biology Cell Biology Psychology & Behavior Molecular Biology

Chronic pain is a maladaptive state that alters nervous system functioning. This results in aberrant and excitable neural networks that manifest in the form of spontaneous pain and the amplification of noxious and innocuous stimuli. Chronic pain modulates and is modulated by cognitive, emotional and mental states including attention, fear and stress. A large focus of my research is to understand the bidirectional interplay between stress and pain. If a person (or mouse) is stressed, simply put, the brain’s ability to filter pain signals is affected in a bad way and pain can be amplified. Each one (pain and stress) can have an impact on the other, creating a vicious cycle that sets the stage for chronic pain and chronic stress. Additionally, we find that processes such as empathy are negatively affected (in mice and humans) by increased social stress and another aspect of my research aims to dissect the underlying biological mechanisms of empathy and prosocial behaviours (using both animal and human subjects). Finally, I am also interested the negative effects that pain has on cognition (learning, memory, brain plasticity) and social interactions when pain is experienced or starts during different developmental time points (neonatal, adolescence, adulthood).

近期论文

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Different immune cells mediate mechanical pain hypersensitivity in male and female mice.Sorge RE, Mapplebeck JC, Rosen S, Beggs S, Taves S, Alexander JK, Martin LJ, Austin JS, Sotocinal SG, Chen D, Yang M, Shi XQ, Huang H, Pillon NJ, Bilan PJ, Tu Y, Klip A, Ji RR, Zhang J, Salter MW, Mogil JS.Nat. Neurosci. 2015 Aug;18(8):1081-3 pubmed Molecular genetic mechanisms of allelic specific regulation of murine Comt expression.Segall SK, Shabalina SA, Meloto CB, Wen X, Cunningham D, Tarantino LM, Wiltshire T, Gauthier J, Tohyama S, Martin LJ, Mogil JS, Diatchenko L.Pain 2015 Oct;156(10):1965-77 pubmed The nicotinic α6 subunit gene determines variability in chronic pain sensitivity via cross-inhibition of P2X2/3 receptors.Wieskopf JS, Mathur J, Limapichat W, Post MR, Al-Qazzaz M, Sorge RE, Martin LJ, Zaykin DV, Smith SB, Freitas K, Austin JS, Dai F, Zhang J, Marcovitz J, Tuttle AH, Slepian PM, Clarke S, Drenan RM, Janes J, Al Sharari S, Segall SK, Aasvang EK, Lai W, Bittner R, Richards CI, Slade GD, Kehlet H, Walker J, Maskos U, Changeux JP, Devor M, Maixner W, Diatchenko L, Belfer I, Dougherty DA, Su AI, Lummis SC, Imad Damaj M, Lester HA, Patapoutian A, Mogil JS.Sci Transl Med 2015 May;7(287):287ra72 pubmed Reducing social stress elicits emotional contagion of pain in mouse and human strangers.Martin LJ, Hathaway G, Isbester K, Mirali S, Acland EL, Niederstrasser N, Slepian PM, Trost Z, Bartz JA, Sapolsky RM, Sternberg WF, Levitin DJ, Mogil JS.Curr. Biol. 2015 Feb;25(3):326-32 pubmed Olfactory exposure to males, including men, causes stress and related analgesia in rodents.Sorge RE, Martin LJ, Isbester KA, Sotocinal SG, Rosen S, Tuttle AH, Wieskopf JS, Acland EL, Dokova A, Kadoura B, Leger P, Mapplebeck JC, McPhail M, Delaney A, Wigerblad G, Schumann AP, Quinn T, Frasnelli J, Svensson CI, Sternberg WF, Mogil JS.Nat. Methods 2014 Jun;11(6):629-32 pubmed The interaction between pain and social behavior in humans and rodents.Martin LJ, Tuttle AH, Mogil JS.Curr Top Behav Neurosci 2014;20:233-50 pubmed Acutely increasing δGABA(A) receptor activity impairs memory and inhibits synaptic plasticity in the hippocampus.Whissell PD, Eng D, Lecker I, Martin LJ, Wang DS, Orser BA.Front Neural Circuits 2013;7:146 pubmed The Rat Grimace Scale: a partially automated method for quantifying pain in the laboratory rat via facial expressions.Sotocinal SG, Sorge RE, Zaloum A, Tuttle AH, Martin LJ, Wieskopf JS, Mapplebeck JC, Wei P, Zhan S, Zhang S, McDougall JJ, King OD, Mogil JS.Mol Pain 2011;7:55 pubmed The sedative but not the memory-blocking properties of ethanol are modulated by α5-subunit-containing γ-aminobutyric acid type A receptors.Martin LJ, Zurek AA, Bonin RP, Oh GH, Kim JH, Mount HT, Orser BA.Behav. Brain Res. 2011 Mar;217(2):379-85 pubmed Short-term memory impairment after isoflurane in mice is prevented by the α5 γ-aminobutyric acid type A receptor inverse agonist L-655,708.Saab BJ, Maclean AJ, Kanisek M, Zurek AA, Martin LJ, Roder JC, Orser BA.Anesthesiology 2010 Nov;113(5):1061-71 pubmed Alpha5GABAA receptor activity sets the threshold for long-term potentiation and constrains hippocampus-dependent memory.Martin LJ, Zurek AA, MacDonald JF, Roder JC, Jackson MF, Orser BA.J. Neurosci. 2010 Apr;30(15):5269-82 pubmed alpha5 Subunit-containing GABA(A) receptors mediate a slowly decaying inhibitory synaptic current in CA1 pyramidal neurons following Schaffer collateral activation.Vargas-Caballero M, Martin LJ, Salter MW, Orser BA, Paulsen O.Neuropharmacology 2010 Mar;58(3):668-75 pubmed