个人简介

Ph.D. University of Victoria B.Sc. University of Alberta

研究领域

Animal Biology Biotechnology Cell Biology Neurobiology Physiology

Our research program is focused on the actions of three families of peptide hormones that encompass metabolism, stress and reproduction. These include 1) teneurin C-terminal associated peptide family; 2) Corticotropin-releasing hormone family, and 3) gonadotropin releasing hormone family. Our interest is how paralogous expansion of stress and metabolism based peptides act to regulate reproduction, growth and behaviour. Current studies utilize mammal, fish and tunicate models to provide and understanding how these systems evolve in vertebrates. Other studies are aimed at developing new approaches for the treatment of human stress associated pathology in the area of neurological, metabolic and fertility disorders.

近期论文

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Repeated intravenous administrations of teneurin-C terminal associated peptide (TCAP)-1 attenuates reinstatement of cocaine seeking by corticotropin-releasing factor (CRF) in rats.Erb S, McPhee M, Brown ZJ, Kupferschmidt DA, Song L, Lovejoy DA.Behav. Brain Res. 2014 Aug;269:1-5 pubmed Molecular evolution of GPCRs: CRH/CRH receptors.Lovejoy DA, Chang BS, Lovejoy NR, del Castillo J.J. Mol. Endocrinol. 2014 Jun;52(3):T43-60 pubmed C-terminal region of teneurin-1 co-localizes with the dystroglycan complex in adult mouse testes and regulates testicular size and testosterone production.Chand D, Colacci M, Dixon K, Kollara A, Brown TJ, Lovejoy DA.Histochem. Cell Biol. 2014 Feb;141(2):191-211 pubmed Appetite-suppressing effects and interactions of centrally administered corticotropin-releasing factor, urotensin I and serotonin in rainbow trout (Oncorhynchus mykiss).Ortega VA, Lovejoy DA, Bernier NJ.Front Neurosci 2013;7:196 pubmed Evolution and phylogeny of the corticotropin-releasing factor (CRF) family of peptides: expansion and specialization in the vertebrates.Lovejoy DA, de Lannoy L.J. Chem. Neuroanat. 2013 Dec;54:50-6 pubmed Teneurin C-terminal associated peptides (TCAP): modulators of corticotropin-releasing factor (CRF) physiology and behavior.Chen Y, Xu M, De Almeida R, Lovejoy DA.Front Neurosci 2013;7:166 pubmed Systems approaches to genomic and epigenetic inter-regulation of peptide hormones in stress and reproduction.Lovejoy DA, Barsyte-Lovejoy D.Prog. Biophys. Mol. Biol. 2013 Dec;113(3):375-86 pubmed Origin of chordate peptides by horizontal protozoan gene transfer in early metazoans and protists: evolution of the teneurin C-terminal associated peptides (TCAP).Chand D, de Lannoy L, Tucker R, Lovejoy DA.Gen. Comp. Endocrinol. 2013 Jul;188:144-50 pubmed C-terminal processing of the teneurin proteins: independent actions of a teneurin C-terminal associated peptide in hippocampal cells.Chand D, Casatti CA, de Lannoy L, Song L, Kollara A, Barsyte-Lovejoy D, Brown TJ, Lovejoy DA.Mol. Cell. Neurosci. 2013 Jan;52:38-50 pubmed Identification of a novel brain derived neurotrophic factor (BDNF)-inhibitory factor: regulation of BDNF by teneurin C-terminal associated peptide (TCAP)-1 in immortalized embryonic mouse hypothalamic cells.Ng T, Chand D, Song L, Al Chawaf A, Watson JD, Boutros PC, Belsham DD, Lovejoy DA.Regul. Pept. 2012 Feb;174(1-3):79-89 pubmed Modulation of neuroplastic changes and corticotropin-releasing factor-associated behavior by a phylogenetically ancient and conserved peptide family.Tan LA, Chand D, De Almeida R, Xu M, De Lannoy L, Lovejoy DA.Gen. Comp. Endocrinol. 2012 May;176(3):309-13 pubmed