个人简介

Ph.D. York 1984

研究领域

Animal Biology Molecular Biology Neurobiology Physiology

The research interests of my laboratory lie within the field of insect physiology. In particular, we are interested in the means by which cells and tissues communicate with one another in order to produce integrated and coordinated output. To this end, we have developed model systems to help identify motor and modulatory input onto the reproductive system, the digestive system and the cardiac system of the locust, Locusta migratoria, the stick insect, Baculum extradentatum, and the medically important hemipteran, Rhodnius prolixus. These inputs must be coordinated in order to produce the correct response at the appropriate time (e.g.egg-laying, absorption of nutrients, circulation). This work entails neurophysiology, neurochemistry, receptor physiology, signal transduction, molecular biology and various physiological bioassays. Our work allows for experimentation at the whole animal level down to the molecular level. Work of this nature can furnish the means of controlling insect pests by development of new insecticides.

近期论文

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Adipokinetic hormone signalling system in the Chagas disease vector, Rhodnius prolixus.Zandawala M, Hamoudi Z, Lange AB, Orchard I.Insect Mol. Biol. 2015 Apr;24(2):264-76 pubmed Myoinhibitors controlling oviduct contraction within the female blood-gorging insect, Rhodnius prolixus.Sedra L, Haddad AS, Lange AB.Gen. Comp. Endocrinol. 2015 Jan;211:62-8 pubmed Identification, characterization and expression of a receptor for the unusual myosuppressin in the blood-feeding bug, Rhodnius prolixus.Lee D, James TE, Lange AB.Insect Mol. Biol. 2015 Feb;24(1):129-37 pubmed Functional characterization and expression analysis of the myoinhibiting peptide receptor in the Chagas disease vector, Rhodnius prolixus.Paluzzi JP, Haddad AS, Sedra L, Orchard I, Lange AB.Mol. Cell. Endocrinol. 2015 Jan;399:143-53 pubmed K+ absorption by locust gut and inhibition of ileal K+ and water transport by FGLamide allatostatins.Robertson L, Donini A, Lange AB.J. Exp. Biol. 2014 Jul; pubmed Octopamine modulates a central pattern generator associated with egg-laying in the locust, Locusta migratoria.Wong R, Lange AB.J. Insect Physiol. 2014 Apr;63:1-8 pubmed The distribution and physiological effects of three evolutionarily and sequence-related neuropeptides in Rhodnius prolixus: Adipokinetic hormone, corazonin and adipokinetic hormone/corazonin-related peptide.Patel H, Orchard I, Veenstra JA, Lange AB.Gen. Comp. Endocrinol. 2014 Jan;195:1-8 pubmed The female reproductive system of the kissing bug, Rhodnius prolixus: arrangements of muscles, distribution and myoactivity of two endogenous FMRFamide-like peptides.Sedra L, Lange AB.Peptides 2014 Mar;53:140-7 pubmed Evidence for a conserved CCAP-signaling pathway controlling ecdysis in a hemimetabolous insect, Rhodnius prolixus.Lee D, Orchard I, Lange AB.Front Neurosci 2013;7:207 pubmed Identification and expression of the CCAP receptor in the Chagas' disease vector, Rhodnius prolixus, and its involvement in cardiac control.Lee D, Vanden Broeck J, Lange AB.PLoS ONE 2013;8(7):e68897 pubmed The distribution and physiological effects of the myoinhibiting peptides in the kissing bug, rhodnius prolixus.Lange AB, Alim U, Vandersmissen HP, Mizoguchi A, Vanden Broeck J, Orchard I.Front Neurosci 2012;6:98 pubmed The neural and peptidergic control of gut contraction in Locusta migratoria: the effect of an FGLa/AST.Robertson L, Rodriguez EP, Lange AB.J. Exp. Biol. 2012 Oct;215(Pt 19):3394-402 pubmed