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个人简介

Ph.D. Michigan State University 2005 M.A. University of British Columbia 2001 B.A. Simon Fraser University 1998

研究领域

Animal Biology Neurobiology Psychology & Behavior

One overarching long-term goal of our research is to better understand how social status influences structure and function in the mammalian brain. To achieve this goal, we study a uniquely social animal: the naked mole-rat. These animals live in large groups with a very strict social hierarchy. By comparing the brains of male and female as well as dominant and subordinate animals, we have demonstrated that, in contrast to most other mammals, social status is more important than sex for determining neural morphology in this species. More recently, we have demonstrated that social status controls adult neurogenesis in the extended limbic system. Our current work is exploring the neuroendocrine mechanisms underlying status-induced plasticity in brain and behaviour, with a particular focus on steroid hormones and oxytocin.

近期论文

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Peripheral administration of oxytocin increases social affiliation in the naked mole-rat (Heterocephalus glaber).Mooney SJ, Douglas NR, Holmes MM.Horm Behav 2014 Apr;65(4):380-5 pubmed A game of thrones: neural plasticity in mammalian social hierarchies.Mooney SJ, Peragine DE, Hathaway GA, Holmes MM.Soc Neurosci 2014;9(2):108-17 pubmed Differential effects of chronic fluoxetine on the behavior of dominant and subordinate naked mole-rats.Mongillo DL, Kosyachkova EA, Nguyen TM, Holmes MM.Behav. Brain Res. 2014 Jan;258:119-26 pubmed Androgen receptor distribution in the social decision-making network of eusocial naked mole-rats.Holmes MM, Van Mil S, Bulkowski C, Goldman SL, Goldman BD, Forger NG.Behav. Brain Res. 2013 Nov;256:214-8 pubmed Socially regulated reproductive development: analysis of GnRH-1 and kisspeptin neuronal systems in cooperatively breeding naked mole-rats (Heterocephalus glaber).Zhou S, Holmes MM, Forger NG, Goldman BD, Lovern MB, Caraty A, Kalló I, Faulkes CG, Coen CW.J. Comp. Neurol. 2013 Sep;521(13):3003-29 pubmed Altered anxiety and defensive behaviors in Bax knockout mice.Luedke AC, Boucher PO, Niel L, Holmes MM.Behav. Brain Res. 2013 Feb;239:115-20 pubmed Maintenance of the spinal nucleus of the bulbocavernosus neuromuscular system is not influenced by physiological levels of glucocorticoids.Niel L, Alves PA, Pinzon N, Holmes MM, Lovern MB, Monks DA.Dev Neurobiol 2012 Aug;72(8):1114-21 pubmed Effects of Bax gene deletion on social behaviors and neural response to olfactory cues in mice.Holmes MM, Niel L, Anyan JJ, Griffith AT, Monks DA, Forger NG.Eur. J. Neurosci. 2011 Nov;34(9):1492-9 pubmed Social status and sex effects on neural morphology in Damaraland mole-rats, Fukomys damarensis.Anyan JJ, Seney ML, Holley A, Bengston L, Goldman BD, Forger NG, Holmes MM.Brain Behav. Evol. 2011;77(4):291-8 pubmed Social and hormonal triggers of neural plasticity in naked mole-rats.Holmes MM, Seney ML, Goldman BD, Forger NG.Behav. Brain Res. 2011 Mar;218(1):234-9 pubmed Sexual dimorphism and hormone responsiveness in the spinal cord of the socially monogamous prairie vole (Microtus ochrogaster).Holmes MM, Musa M, Lonstein JS, Monks DA.J. Comp. Neurol. 2009 Sep;516(2):117-24 pubmed Neuroendocrinology and sexual differentiation in eusocial mammals.Holmes MM, Goldman BD, Goldman SL, Seney ML, Forger NG.Front Neuroendocrinol 2009 Oct;30(4):519-33 pubmed

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