个人简介

Ph.D. Toronto 2003 B.Sc., Western 1996

研究领域

Cell Biology Developmental Biology Molecular Biology Systems Biology

We study the molecular bases of how animal cells and tissues are built. We use confocal and time-lapse microscopy in combination with Drosophila genetics and molecular biology to study how epithelial cells are formed and re-shaped during development. Epithelia are sheets of adherent cells that form boundaries between our body compartments. Each side of an epithelial sheet has distinct molecular properties. This epithelial polarity is critical for guiding embryo development and directing adult functions (e.g. nutrient uptake in the gut), and its loss is associated with cancer. We are focusing on the molecular machinery responsible for forming epithelial cells (polarity, adhesion, cytoskeletal and membrane trafficking complexes). We are identifying the proteins making up this machinery and determining how they function together in short-range and long-range circuits to establish, maintain and remodel epithelial structure in the Drosophila embryo.

近期论文

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The Arf GAP Asap promotes Arf1 function at the Golgi for cleavage furrow biosynthesis in Drosophila.Rodrigues, Francisco F, Wei Shao, and Tony J C Harris. 2016. Molecular biology of the cell, no. 20 ( 17). pubmed Cadherin trafficking for tissue morphogenesis: control and consequences. West, Junior J, and Tony J C Harris. 2016. Traffic (Copenhagen, Denmark) ( 23). doi:10.1111/tra.12407. pubmed PH Domain-Arf G Protein Interactions Localize the Arf-GEF Steppke for Cleavage Furrow Regulation in Drosophila.Lee DM, Rodrigues FF, Yu CG, Swan M, Harris TJ.PLoS ONE 2015;10(11):e0142562 pubmed A Par-1-Par-3-Centrosome Cell Polarity Pathway and Its Tuning for Isotropic Cell Adhesion.Jiang T, McKinley RF, McGill MA, Angers S, Harris TJ.Curr. Biol. 2015 Oct;25(20):2701-8 pubmed Polarized E-cadherin endocytosis directs actomyosin remodeling during embryonic wound repair.Hunter MV, Lee DM, Harris TJ, Fernandez-Gonzalez R.J. Cell Biol. 2015 Aug;210(5):801-16 pubmed Germ Cell Segregation from the Drosophila Soma Is Controlled by an Inhibitory Threshold Set by the Arf-GEF Steppke.Lee DM, Wilk R, Hu J, Krause HM, Harris TJ.Genetics 2015 Jul;200(3):863-72 pubmed Stepping stone: a cytohesin adaptor for membrane cytoskeleton restraint in the syncytial Drosophila embryo.Liu J, Lee DM, Yu CG, Angers S, Harris TJ.Mol. Biol. Cell 2015 Feb;26(4):711-25 pubmed Coordinating the cytoskeleton and endocytosis for regulated plasma membrane growth in the early Drosophila embryo.Lee DM, Harris TJ.Bioarchitecture 2014 Mar-Apr;4(2):68-74 pubmed Peptide binding properties of the three PDZ domains of Bazooka (Drosophila Par-3).Yu CG, Tonikian R, Felsensteiner C, Jhingree JR, Desveaux D, Sidhu SS, Harris TJ.PLoS ONE 2014;9(1):e86412 pubmed Adherens junction distribution mechanisms during cell-cell contact elongation in Drosophila.Goldenberg G, Harris TJ.PLoS ONE 2013;8(11):e79613 pubmed Bazooka inhibits aPKC to limit antagonism of actomyosin networks during amnioserosa apical constriction.David DJ, Wang Q, Feng JJ, Harris TJ.Development 2013 Dec;140(23):4719-29 pubmed An Arf-GEF regulates antagonism between endocytosis and the cytoskeleton for Drosophila blastoderm development.Lee DM, Harris TJ.Curr. Biol. 2013 Nov;23(21):2110-20 pubmed