个人简介

Ph.D. Stony Brook University 1994 B.Sc. Washington University in St. Louis 1987

研究领域

Bioinformatics & Computational Biology Comparative Genomics Evolutionary Biology Functional Genomics Genetics Microbiology Pathology Plant Biology

The Guttman lab has two major foci. First, we are studying the evolution of host specificity and virulence in pathogenic bacteria. We are specifically interested in identifying the genetic determinants of host specificity, and determining what factors determine if a particular bacterial-host interaction is benign or results in disease. Our work will lead to a better understanding of where the genetic potential for virulence originates and how is it maintained in bacterial populations. Most of this work is done with the agriculturally important plant pathogen Pseudomonas syringae and the model plant Arabidopsis thaliana. Our second focus is on the structure, dynamics, and function of bacterial communities (microbiomes) associated with both humans and plants. We are specifically interested in understanding how polymicrobial communities influence the expression and course of disease. Microbiomes have been shown to dramatically influence immune development and disease resistance and progression. Most of this work is focused on cystic fibrosis, and plant resistance, although we also study a number of other human pathologies such as inflammatory bowel disease. We use a wide range of comparative, evolutionary and functional genomic approaches in the group. We have a particularly strong emphasis on using evolutionary and bioinformatic approaches to generate hypotheses that can then be functionally validated through traditional molecular and biochemical assays.

近期论文

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Impact of maternal intrapartum antibiotics, method of birth and breastfeeding on gut microbiota during the first year of life: a prospective cohort study.Azad, M B, T Konya, R R Persaud, D S Guttman, R S Chari, C J Field, M R Sears, et al. 2015. BJOG : an international journal of obstetrics and gynaecology, no. 6 (September 28). doi:10.1111/1471-0528.13601. pubmed Evolution, genomics and epidemiology of Pseudomonas syringae: Challenges in Bacterial Molecular Plant Pathology.Baltrus, David A, Honour C McCann, and David S Guttman. 2016. Molecular plant pathology, no. 1 (November 25). doi:10.1111/mpp.12506. pubmed Prophages mediate defense against phage infection through diverse mechanisms.Bondy-Denomy, Joseph, Jason Qian, Edze R Westra, Angus Buckling, David S Guttman, Alan R Davidson, and Karen L Maxwell. 2016. The ISME journal, no. 12 (June 3). doi:10.1038/ismej.2016.79. pubmed High fecal IgA is associated with reduced Clostridium difficile colonization in infants.Bridgman, Sarah L, Tedd Konya, Meghan B Azad, David S Guttman, Malcolm R Sears, Allan B Becker, Stuart E Turvey, et al. 2016. Microbes and infection, no. 9 (May 24). doi:10.1016/j.micinf.2016.05.001. pubmed Oral Vancomycin Followed by Fecal Transplantation Versus Tapering Oral Vancomycin Treatment for Recurrent Clostridium difficile Infection: An Open-Label, Randomized Controlled Trial.Hota, Susy S, Valerie Sales, George Tomlinson, Mary Jane Salpeter, Allison McGeer, Bryan Coburn, David S Guttman, Donald E Low, and Susan M Poutanen. 2016. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (November 9). doi:ciw731. pubmed Image-Based Quantification of Plant Immunity and Disease.Laflamme, Bradley, Maggie Middleton, Timothy Lo, Darrell Desveaux, and David S Guttman. 2016. Molecular plant-microbe interactions : MPMI (December 20). pubmed Disentangling Interactions in the Microbiome: A Network Perspective. Layeghifard, Mehdi, David M Hwang, and David S Guttman. 2016. Trends in microbiology (December 1). doi:S0966-842X(16)30185-8. pubmed The HopF family of Pseudomonas syringae type III secreted effectors.Lo, Timothy, Noushin Koulena, Derek Seto, David S Guttman, and Darrell Desveaux. 2016. Molecular plant pathology (April 6). doi:10.1111/mpp.12412. pubmed Genomic screens identify a new phytobacterial microbe-associated molecular pattern and the cognate Arabidopsis receptor-like kinase that mediates its immune elicitation.Mott, G Adam, Shalabh Thakur, Elwira Smakowska, Pauline W Wang, Youssef Belkhadir, Darrell Desveaux, and David S Guttman. 2016. Genome biology (May 9). doi:10.1186/s13059-016-0955-7. pubmed Metabolic Reprogramming by Hexosamine Biosynthetic and Golgi N-Glycan Branching Pathways.Ryczko, Michael C, Judy Pawling, Rui Chen, Anas M Abdel Rahman, Kevin Yau, Julia K Copeland, Cunjie Zhang, et al. 2016. Scientific reports (March 14). doi:10.1038/srep23043. pubmed NKT Cell-Deficient Mice Harbor an Altered Microbiota That Fuels Intestinal Inflammation during Chemically Induced Colitis. Selvanantham, Thirumahal, Qiaochu Lin, Cynthia Xinyi Guo, Anuradha Surendra, Stephanie Fieve, Nichole K Escalante, David S Guttman, et al. 2016. Journal of immunology (Baltimore, Md. : 1950), no. 11 (October 31). pubmed A De-Novo Genome Analysis Pipeline (DeNoGAP) for large-scale comparative prokaryotic genomics studies.Thakur, Shalabh, and David S Guttman. 2016. BMC bioinformatics, no. 1 (June 30). doi:10.1186/s12859-016-1142-2. pubmed