个人简介

Postdoctoral research 1991-1996, UCLA, USA Ph.D. 1990, University of Cologne, Germany Diploma 1985, Lud. Max. University Munich, Germany

研究领域

Animal Biology Cell Biology Developmental Biology Functional Genomics Genetics Molecular Biology

The behavior of individual cells is the driving force behind morphogenesis. Cell shape, cell motility, cell-cell and cell-matrix interactions, which can undergo rapid changes during development, determine the shape and organization of tissues and organs. To identify and analyze the molecular pathways and networks that regulate the behavior of cells during morphogenesis my research group uses gonad development in Drosophila as a model system. Our research focuses on (1) the formation of the germline stem cell niche, (2) invasive cell migration in ovarian follicles, and (3) development of microvilli in epithelial cells.

近期论文

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The E3 ligase Ubr3 regulates Usher syndrome and MYH9 disorder proteins in the auditory organs of Drosophila and mammals.Li, Tongchao, Nikolaos Giagtzoglou, Daniel F Eberl, Sonal Nagarkar Jaiswal, Tiantian Cai, Dorothea Godt, Andrew K Groves, and Hugo J Bellen. eLife (June 22) 2016. doi:10.7554/eLife.15258. pubmed Loss of SPARC dysregulates basal lamina assembly to disrupt larval fat body homeostasis in Drosophila melanogaster.Shahab J, Baratta C, Scuric B, Godt D, Venken KJ, Ringuette MJ.Dev. Dyn. 2014 Dec; pubmed Myosin VIIA regulates microvillus morphogenesis and interacts with cadherin Cad99C in Drosophila oogenesis.Glowinski C, Liu RH, Chen X, Darabie A, Godt D.J. Cell. Sci. 2014 Nov;127(22):4821-32 pubmed The Maf factor Traffic jam both enables and inhibits collective cell migration in Drosophila oogenesis.Gunawan F, Arandjelovic M, Godt D.Development 2013 Jul;140(13):2808-17 pubmed Mutational analysis supports a core role for Drosophila α-catenin in adherens junction function.Sarpal R, Pellikka M, Patel RR, Hui FY, Godt D, Tepass U.J. Cell. Sci. 2012 Jan;125(Pt 1):233-45 pubmed Breaking a temporal barrier: signalling crosstalk regulates the initiation of border cell migration.Godt D, Tepass U.Nat. Cell Biol. 2009 May;11(5):536-8 pubmed The germline stem cells of Drosophila melanogaster partition DNA non-randomly.Karpowicz P, Pellikka M, Chea E, Godt D, Tepass U, van der Kooy D.Eur. J. Cell Biol. 2009 Jul;88(7):397-408 pubmed Cell dynamics and developmental bias in the ontogeny of a complex sexually dimorphic trait in Drosophila melanogaster.Atallah J, Liu NH, Dennis P, Hon A, Godt D, Larsen EW.Evol. Dev. 2009 Mar-Apr;11(2):191-204 pubmed Expression profile of the cadherin family in the developing Drosophila brain.Fung S, Wang F, Chase M, Godt D, Hartenstein V.J. Comp. Neurol. 2008 Jan;506(3):469-88 pubmed Integrin-dependent anchoring of a stem-cell niche.Tanentzapf G, Devenport D, Godt D, Brown NH.Nat. Cell Biol. 2007 Dec;9(12):1413-8 pubmed Drosophila melanogaster Cad99C, the orthologue of human Usher cadherin PCDH15, regulates the length of microvilli.D’Alterio C, Tran DD, Yeung MW, Hwang MS, Li MA, Arana CJ, Mulligan VK, Kubesh M, Sharma P, Chase M, Tepass U, Godt D.J. Cell Biol. 2005 Nov;171(3):549-58 pubmed Talin’s second persona.Tepass U, Godt D.Nat. Cell Biol. 2005 May;7(5):443-4 pubmed