个人简介

Ph.D. Eberhard Karls University of Tuebingen, Germany 2000 M.Sc. University of Milan, Italy 1996 University of Milan, Italy 1994

研究领域

Cell Biology Developmental Biology Functional Genomics Genetics Molecular Biology Plant Biology

Seeds constitute the majority of global food intake worldwide. Seeds of most temperate plant species show different degrees of dormancy and integrate a variety of endogenous and environmental signals to coordinate development and germinate under favorable conditions. Understanding the timing of dormancy break and germination is important from an agronomical point of view. Reduced dormancy causes “pre-harvest sprouting” in several crop varieties, which results in downgrading of grains, while increased dormancy delays germination and results in a shorter growth season. We study the molecular mechanisms that regulate the transition from dormancy to germination and the role that hormones, nutrients and abiotic stresses play in these processes. We use functional genomics, molecular and genetic approaches to identify and characterize key players involved in the regulation of dormancy and germination. Currently, we are characterizing protein complexes identified by yeast-two-hybrid and Bimolecular Fluorescence Complementation (BiFC) assays important for the regulation of these processes. We are also studying transcriptional and post-translational regulation of master regulators of seed development and germination in response to abiotic stresses and hormones in the model plant Arabidopsis.

近期论文

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ABA-dependent inhibition of the ubiquitin proteasome system during germination at high temperature in Arabidopsis.Chiu RS, Pan S, Zhao R, Gazzarrini S. Plant J. 2016 Dec;88(5):749-761. doi: 10.1111/tpj.13293. pubmed Inhibition of FUSCA3 degradation at high temperature is dependent on ABA signaling and is regulated by the ABA/GA ratio..Chiu RS, Saleh Y, Gazzarrini S. Plant Signal Behav. 2016 Nov;11(11):e1247137. pubmed Hormone cross-talk during seed germination.Gazzarrini S, Tsai AY. Essays Biochem. 2015;58:151-64. doi: 10.1042/bse0580151. Review. pubmed Trehalose-6-phosphate and SnRK1 kinases in plant development and signaling: the emerging picture.Tsai AY, Gazzarrini S.Front Plant Sci 2014;5:119 pubmed Overlapping and distinct roles of AKIN10 and FUSCA3 in ABA and sugar signaling during seed germination.Tsai AY, Gazzarrini S.Plant Signal Behav 2012 Oct;7(10):1238-42 pubmed The embryonic leaf identity gene FUSCA3 regulates vegetative phase transitions by negatively modulating ethylene-regulated gene expression in Arabidopsis.Lumba S, Tsuchiya Y, Delmas F, Hezky J, Provart NJ, Shi Lu Q, McCourt P, Gazzarrini S.BMC Biol. 2012;10:8 pubmed The role of the Arabidopsis FUSCA3 transcription factor during inhibition of seed germination at high temperature.Chiu RS, Nahal H, Provart NJ, Gazzarrini S.BMC Plant Biol. 2012;12:15 pubmed AKIN10 and FUSCA3 interact to control lateral organ development and phase transitions in Arabidopsis.Tsai AY, Gazzarrini S.Plant J. 2012 Mar;69(5):809-21 pubmed The C-terminal domain of FUSCA3 negatively regulates mRNA and protein levels, and mediates sensitivity to the hormones abscisic acid and gibberellic acid in Arabidopsis.Lu QS, Paz JD, Pathmanathan A, Chiu RS, Tsai AY, Gazzarrini S.Plant J. 2010 Oct;64(1):100-13 pubmed Additive contribution of AMT1;1 and AMT1;3 to high-affinity ammonium uptake across the plasma membrane of nitrogen-deficient Arabidopsis roots.Loqué D, Yuan L, Kojima S, Gojon A, Wirth J, Gazzarrini S, Ishiyama K, Takahashi H, von Wirén N.Plant J. 2006 Nov;48(4):522-34 pubmed Crosstalk and abscisic acid: the roles of terpenoid hormones in coordinating developmentMcCourt P, Lumba S, Tsuchiya Y, Gazzarrini S. Physiologia Plantarum 2005 Feb;123(2):147-152 DOI: 10.1111/j.1399-3054.2005.00457.x