个人简介

PhD, Concordia University, 2000 MA, Concordia University, 1996 BSc, Wilfrid Laurier University, 1995

研究领域

Animal Biology Neurobiology Psychology & Behavior

My general research interests concern the neurobiology of relapse to drug seeking and the interface between neurobiology and behavior in the study of substance abuse. I am particularly interested in how the brain changes at neurotransmitter system and gene expression levels as a consequence of a history of drug exposure, and how these changes are manifest in behavior. Although a number of significant neurobiological changes occur in the early stages of drug withdrawal (first several days), it is the potential for enduring, long-term changes (those that persist or may only emerge after weeks or months of withdrawal), and how these changes may render a former user vulnerable to episodes of relapse, that is of particular interest to me.

近期论文

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Repeated intravenous administrations of teneurin-C terminal associated peptide (TCAP)-1 attenuates reinstatement of cocaine seeking by corticotropin-releasing factor (CRF) in rats.Erb S, McPhee M, Brown ZJ, Kupferschmidt DA, Song L, Lovejoy DA.Behav. Brain Res. 2014 Aug;269:1-5 pubmed Cocaine exposure prior to pregnancy alters the psychomotor response to cocaine and transcriptional regulation of the dopamine D1 receptor in adult male offspring.Sasaki A, Constantinof A, Pan P, Kupferschmidt DA, McGowan PO, Erb S.Behav. Brain Res. 2014 May;265:163-70 pubmed Ecologically valid assessment of executive dysfunction using a novel virtual reality task in patients with acquired brain injury.Jovanovski D, Zakzanis K, Ruttan L, Campbell Z, Erb S, Nussbaum D.Appl Neuropsychol Adult 2012;19(3):207-20 pubmed Development of a novel, ecologically oriented virtual reality measure of executive function: the Multitasking in the City Test.Jovanovski D, Zakzanis K, Campbell Z, Erb S, Nussbaum D.Appl Neuropsychol Adult 2012;19(3):171-82 pubmed Reinstatement of cocaine seeking in rats by the pharmacological stressors, corticotropin-releasing factor and yohimbine: role for D1/5 dopamine receptors.Brown ZJ, Kupferschmidt DA, Erb S.Psychopharmacology (Berl.) 2012 Dec;224(3):431-40 pubmed Expression and resilience of a cocaine-conditioned locomotor response after brief and extended drug-free periods.Johnson SA, Sediqzadah S, Erb S.Behav. Brain Res. 2012 Apr;230(1):69-77 pubmed A procedure for studying the footshock-induced reinstatement of cocaine seeking in laboratory rats.Kupferschmidt DA, Brown ZJ, Erb S.J Vis Exp 2011;(47) pubmed Central injections of noradrenaline induce reinstatement of cocaine seeking and increase c-fos mRNA expression in the extended amygdala.Brown ZJ, Nobrega JN, Erb S.Behav. Brain Res. 2011 Mar;217(2):472-6 pubmed Teneurin C-terminal associated peptide-1 blocks the effects of corticotropin-releasing factor on reinstatement of cocaine seeking and on cocaine-induced behavioural sensitization.Kupferschmidt DA, Lovejoy DA, Rotzinger S, Erb S.Br. J. Pharmacol. 2011 Feb;162(3):574-83 pubmed Age-related effects of acute nicotine on behavioural and neuronal measures of anxiety.Kupferschmidt DA, Funk D, Erb S, Lê AD.Behav. Brain Res. 2010 Dec;213(2):288-92 pubmed Evaluation of the relationship between anxiety during withdrawal and stress-induced reinstatement of cocaine seeking.Erb S.Prog. Neuropsychopharmacol. Biol. Psychiatry 2010 Jun;34(5):798-807 pubmed Role of CRF and other neuropeptides in stress-induced reinstatement of drug seeking.Shalev U, Erb S, Shaham Y.Brain Res. 2010 Feb;1314:15-28 pubmed