个人简介

Ph.D. University of Montreal 2002 M.Sc. McGill University 1998 B.Sc. McGill University 1997

研究领域

Biotechnology Chemical Biology Functional Genomics Genetics Microbiology Molecular Biology Pathology Plant Biology Proteomics Structural Biology Systems Biology

Strains of the phytopathogen Pseudomonas syringae can infect and cause disease in hundreds of plant species. Like many Gram-negative bacterial pathogens, the ability of P. syringae to cause disease is dependent on the type III secretion system and the effector proteins delivered into host cells via this system. A current challenge in the study of plant pathology is to understand the pathogenic advantage conveyed by type III effectors on susceptible host plants. P. syringae possesses an arsenal of type III effector proteins (up to 40 in some strains) which it injects into host cells. These effectors play a central role in determining the outcome of an interaction with a potential host. The Desveaux lab aims to understand how the network of biological events induced by the arsenal of P. syringae type III effectors allows this plant pathogen to overcome its host’s defences and establish and/or maintain a favourable environment for pathogenesis. Since host targets of type III effectors include critical components of disease resistance signalling networks, we also contribute to the understanding of host defence responses. We are using proteomics, structural biology, chemical biology, genetics and biochemistry to elucidate the molecular mechanisms of pathogen virulence and host resistance.

近期论文

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The Pseudomonas syringae Type III Effector HopF2 Suppresses Arabidopsis Stomatal Immunity.Hurley B, Lee D, Mott A, Wilton M, Liu J, Liu YC, Angers S, Coaker G, Guttman DS, Desveaux D.PLoS ONE 2014;9(12):e114921 pubmed Proteomics of effector-triggered immunity (ETI) in plants.Hurley B, Subramaniam R, Guttman DS, Desveaux D.Virulence 2014 Sep;5(7) pubmed The ABCs and 123s of Bacterial Secretion Systems in Plant Pathogenesis.Chang JH, Desveaux D, Creason AL.Annu Rev Phytopathol 2014 Aug;52:317-45 pubmed A mesoscale abscisic acid hormone interactome reveals a dynamic signaling landscape in Arabidopsis.Lumba S, Toh S, Handfield LF, Swan M, Liu R, Youn JY, Cutler SR, Subramaniam R, Provart N, Moses A, Desveaux D, McCourt P.Dev. Cell 2014 May;29(3):360-72 pubmed Peptide binding properties of the three PDZ domains of Bazooka (Drosophila Par-3).Yu CG, Tonikian R, Felsensteiner C, Jhingree JR, Desveaux D, Sidhu SS, Harris TJ.PLoS ONE 2014;9(1):e86412 pubmed The rise of the undead: Pseudokinases as mediators of effector-triggered immunity.Lewis JD, Lo T, Bastedo P, Guttman DS, Desveaux D.Plant Signal Behav 2014 Jan;9(1) pubmed Arabidopsis GOLDEN2-LIKE (GLK) transcription factors activate jasmonic acid (JA)-dependent disease susceptibility to the biotrophic pathogen Hyaloperonospora arabidopsidis, as well as JA-independent plant immunity against the necrotrophic pathogen Botrytis cinerea.Murmu J, Wilton M, Allard G, Pandeya R, Desveaux D, Singh J, Subramaniam R.Mol. Plant Pathol. 2014 Feb;15(2):174-84 pubmed Next-generation mapping of genetic mutations using bulk population sequencing.Austin RS, Chatfield SP, Desveaux D, Guttman DS.Methods Mol. Biol. 2014;1062:301-15 pubmed The Arabidopsis ZED1 pseudokinase is required for ZAR1-mediated immunity induced by the Pseudomonas syringae type III effector HopZ1a.Lewis JD, Lee AH, Hassan JA, Wan J, Hurley B, Jhingree JR, Wang PW, Lo T, Youn JY, Guttman DS, Desveaux D.Proc. Natl. Acad. Sci. U.S.A. 2013 Nov;110(46):18722-7 pubmed Phytopathogen type III effectors as probes of biological systems.Lee AH, Middleton MA, Guttman DS, Desveaux D.Microb Biotechnol 2013 May;6(3):230-40 pubmed Forward chemical genetic screens in Arabidopsis identify genes that influence sensitivity to the phytotoxic compound sulfamethoxazole.Schreiber KJ, Austin RS, Gong Y, Zhang J, Fung P, Wang PW, Guttman DS, Desveaux D.BMC Plant Biol. 2012;12:226 pubmed A high-throughput forward genetic screen identifies genes required for virulence of Pseudomonas syringae pv. maculicola ES4326 on Arabidopsis.Schreiber KJ, Ye D, Fich E, Jian A, Lo T, Desveaux D.PLoS ONE 2012;7(8):e41461 pubmed