个人简介

Ph.D. University of Texas 1969 B.Sc. Carleton University 1966

研究领域

Cell Biology Molecular Biology Neurobiology

The frequency of neurodegenerative diseases in the human population is increasing as average life span lengthens, hence the search for effective therapies is a pressing challenge. Neurodegenerative diseases have been termed ‘protein misfolding disorders’ as aggregation-prone, misfolded proteins accumulated in neural cells triggering pathogenic cascades that result in cell death of specific population of neurons in the brain. Heat shock proteins are ‘protein repair agents’ that can detect misfolded proteins and facilitated their correct refolding. Upregulation of heat shock proteins in the nervous system is being explored in my laboratory as a potential strategy to combat neurodegenerative diseases that have been classified as protein misfolding disorders.

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Heat shock response and homeostatic plasticity.Karunanithi S, Brown IR.Front Cell Neurosci 2015;9:68 pubmed Localization of heat shock protein HSPA6 (HSP70B') to sites of transcription in cultured differentiated human neuronal cells following thermal stress.Khalouei S, Chow AM, Brown IR.J. Neurochem. 2014 Dec;131(6):743-54 pubmed Electrochemical immunosensors for effective evaluation of amyloid-beta modulators on oligomeric and fibrillar aggregation processes.Veloso AJ, Chow AM, Ganesh HV, Li N, Dhar D, Wu DC, Mikhaylichenko S, Brown IR, Kerman K.Anal. Chem. 2014 May;86(10):4901-9 pubmed Localization of heat shock proteins in cerebral cortical cultures following induction by celastrol.Chow AM, Tang DW, Hanif A, Brown IR.Cell Stress Chaperones 2014 Apr; pubmed Stress-induced localization of HSPA6 (HSP70B') and HSPA1A (HSP70-1) proteins to centrioles in human neuronal cells.Khalouei S, Chow AM, Brown IR.Cell Stress Chaperones 2014 May;19(3):321-7 pubmed Quantum dot based fluorometric detection of cancer TF-antigen.Li N, Chow AM, Ganesh HV, Brown IR, Kerman K.Anal. Chem. 2013 Oct;85(20):9699-704 pubmed Biological activity of sym-triazines with acetylcholine-like substitutions as multitarget modulators of Alzheimer's disease.Veloso AJ, Chow AM, Dhar D, Tang DW, Ganesh HV, Mikhaylichenko S, Brown IR, Kerman K.ACS Chem Neurosci 2013 Jun;4(6):924-9 pubmed sym-Triazines for directed multitarget modulation of cholinesterases and amyloid-β in Alzheimer's disease.Veloso AJ, Dhar D, Chow AM, Zhang B, Tang DW, Ganesh HV, Mikhaylichenko S, Brown IR, Kerman K.ACS Chem Neurosci 2013 Feb;4(2):339-49 pubmed Induction of heat shock proteins in cerebral cortical cultures by celastrol.Chow AM, Tang DW, Hanif A, Brown IR.Cell Stress Chaperones 2013 Mar;18(2):155-60 pubmed CSSI workshop in Brazil highlights "Stress Responses in the Nervous System" in relation to neurodegenerative diseases and neuroprotection.Brown IR.Cell Stress Chaperones 2012 Nov;17(6):657-60 pubmed Oxidative stress effect of dopamine on α-synuclein: electroanalysis of solvent interactions.Chan T, Chow AM, Cheng XR, Tang DW, Brown IR, Kerman K.ACS Chem Neurosci 2012 Jul;3(7):569-74 pubmed Hsp60 protein pattern in coral is altered by environmental changes in light and temperature.Chow AM, Beraud E, Tang DW, Ferrier-Pagès C, Brown IR.Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. 2012 Mar;161(3):349-53 pubmed