研究领域

Neurobiology Physiology Systems Biology Cell Biology Animal Biology

Early life experiences crucially define cognitive and mental health function throughout life. Childhood and adolescence are the predominant age of onset for the majority of mental disorders and are periods during which key brain areas involved in emotional processing are maturing. Still, it is unclear how these changes in brain development influence circuit function and as a consequence affect behaviour and the onset of mental illness. Our research focuses on understanding how the maturation of sensitive brain circuits underlies the emergence of complex behaviour and sensitivity to stress in mice. We are exploring this using a combination of patch clamp recordings, immunohistochemistry, behaviour, and in vitro and in vivo optogenetics. Our lab uses a systems level approach to explore the relationship between the maturation of sensitive brain circuits, the emergence of complex behaviour, and stress sensitivity in mice.

近期论文

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Arruda-Carvalho M, Clem RL. Prefrontal-amygdala fear networks come into focus. Front Syst Neurosci 9:145, 2015. PMID:26578902 Arruda-Carvalho M, Clem RL. Pathway-selective adjustment of prefrontal-amygdala transmission during fear encoding. Journal of Neuroscience 34(47):15601-9, 2014 PMID:25411488 Arruda-Carvalho M, Akers KG, Guskjolen A, Sakaguchi M, Josselyn SA, Frankland PW. Post-training ablation of adult-generated olfactory granule cells degrades odor-reward memories. Journal of Neuroscience 34(47):15793-803, 2014 PMID:25411506 Arruda-Carvalho M, Restivo L, Guskjolen A, Epp JR, Elgersma Y, Josselyn SA, Frankland PW. Conditional Deletion of α-CaMKII Impairs Integration of Adult-Generated Granule Cells into Dentate Gyrus Circuits and Hippocampus-Dependent Learning. Journal of Neuroscience 34(36): 11919-28 (2014) PMID:25186740 Akers KG, Arruda-Carvalho M, Josselyn SA, Frankland PW. Ontogeny of contextual fear memory formation, specificity, and persistence in mice. Learning & Memory. 19(12):598-604 (2012). PMID:23161449 Gu Y, Arruda-Carvalho M, Wang J, Janoschka S, Josselyn SA, Frankland PW, Ge S. Optical controlling reveals time-dependent roles for adult-born dentate granule cells. Nature Neuroscience 15(12):1700-6. (2012) PMID:23143513 Arruda-Carvalho M, Sakaguchi M, Akers KG, Josselyn SA, Frankland PW. Posttraining ablation of adult-generated neurons degrades previously acquired memories. Journal of Neuroscience 31(42):15113-27(2011) Comment in Nature 478 (7370) 431. PMID:22016545