Rand, Margaret L. - University of Toronto - Department of Biochemistry

个人简介

Dr. Margaret Rand obtained her PhD in Biochemistry on the topic of platelet senescence at the University of Toronto, and completed her research training in platelets and arterial thrombosis during Post-Doctoral Fellowships at the Universiteit Maastricht in the Netherlands and at McMaster University. She is currently a Professor in the Departments of Laboratory Medicine and Pathobiology, of Biochemistry, and of Pediatrics at the University of Toronto. At the Hospital for Sick Children in Toronto, where she co-directs the Clinical Hemostasis and Thrombosis Research Laboratory, Dr. Rand is a Senior Associate Scientist in the Pediatric Thrombosis and Hemostasis Program of the Division of Haematology/Oncology and in the Physiology and Experimental Medicine Program of the Research Institute. Dr. Rand’s career-long research interest has been in blood platelet function and dysfunction, with a translation research focus on standardized pediatric bleeding questionnaires. She presently serves on the Board of Directors of the Canadian Society for Atherosclerosis, Thrombosis and Vascular Biology. She is Co-Chair of the Rare Inherited Bleeding Disorders Subcommittee of the Association of Hemophilia Clinic Directors of Canada, a member of the Hemostasis Committee of the Canadian Pediatric Thrombosis and Hemostasis Network, and a member of the Joint Bleeding Score Working Group of the ISTH and the Local Organizing Committee for ISTH 2015.

研究领域

We will be investigating polymorphisms in platelet membrane glycoproteins that can lead to an increased risk of bleeding complications, or of arterial thrombosis.

近期论文

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Phosphatidylserine exposure, microparticle formation and mitochondrial depolarisation in Glanzmann thrombasthenia platelets. Wang H, Bang KW, Blanchette VS, Nurden AT, Rand ML. Thromb Haemost. 2014 Jun;111(6):1184-6 Read Diannexin, an annexin A5 homodimer, binds phosphatidylserine with high affinity and is a potent inhibitor of platelet-mediated events during thrombus formation. Rand ML, Wang H, Pluthero FG, Stafford AR, Ni R, Vaezzadeh N, Allison AC, Kahr WH, Weitz JI, Gross PL. J Thromb Haemost. 2012 Jun;10(6):1109-19. Read Historical perspective on ADP-induced platelet activation. Packham MA, Rand ML. Purinergic Signal. 2011 Sep;7(3):283-92. Read