Wyatt, Haley - University of Toronto - Department of Biochemistry

个人简介

Haley Wyatt was born and raised in the small rural community of Broadview, Saskatchewan (Canada). Her research training in biochemistry and molecular biology began during her postgraduate studies at the Southern Alberta Cancer Research Institute and the University of Calgary. Under the supervision of Tara Beattie, she studied the human telomerase reverse transcriptase (hTERT). hTERT is the catalytic subunit of telomerase, an enzyme that has a pivotal role in cellular proliferation and organismal aging and is deregulated in many types of cancer. Haley developed the first biochemical assay to study interactions between hTERT and telomeric DNA substrates. This assay was critical for subsequent structure-function studies, in which she provided important insight into the molecular mechanisms of telomerase deficiency associated with human disease. After receiving her PhD in 2009, Haley moved to Stephen West’s laboratory at the Francis Crick Institute (formerly Clare Hall Laboratories) in London, England to pursue her interests in DNA repair and mechanisms of genome instability. Her research has significantly advanced our understanding of the biochemical and cellular functions of the SLX4 protein and its role as a scaffold for an endonuclease DNA repair complex. This research is of particular relevance to human health because mutations in SLX4 (and its associated nucleases) are linked to Fanconi anemia, a complex disorder characterized by bone marrow failure, chromosomal instability, and cancer susceptibility. In 2017, Haley will move back to Canada to open her lab in the Department of Biochemistry.

研究领域

The Wyatt lab will open in April 2017! We will study the structure, function, and regulation of nucleases. These enzymes are scissors that have critical roles in repairing damaged DNA and maintaining genome stability. The lab will use a powerful combination of techniques in biochemistry and molecular biology, including protein expression and purification, enzymology, proteomics, microscopy, and phenotypic analyses of cultured human cells. Research opportunities are available for enthusiastic, positive, and highly-motivated individuals that seek to understand how human cells maintain genome stability, and how protein dysfunction gives rise to human disease. Successful candidates will have an exciting opportunity to help build the Wyatt lab from the “ground-up” and will benefit from working alongside the Principal Investigator, who will provide them with direct mentorship and training.

近期论文

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Detection of gas phase chemical warfare agents using field-portable gas chromatography-mass spectrometry systems: instrument and sampling strategy considerations Smith Phil, Jackson-Lepage C, Koch D, Wyatt HDM, Eckenrode B, Hook G, Betsinger G. Trends in analytical chemistry : TRAC. 2004; 23:296-306. My Bibliography [journal] Select item at position 2 Characterization of physical and functional anchor site interactions in human telomerase. Wyatt HD, Lobb DA, Beattie TL. Molecular and cellular biology. 2007; 27(8):3226-40. PubMed [journal] PMID: 17296728 PMCID: PMC1899913 Select item at position 3 Cell wall architecture of Physcomitrella patens is revealed by atomic force microscopy Wyatt HDM, Ashton NeilW, Dahms TES. Botany. 2008; 86:385-397. My Bibliography [journal] Select item at position 4 Human telomerase reverse transcriptase (hTERT) Q169 is essential for telomerase function in vitro and in vivo. Wyatt HD, Tsang AR, Lobb DA, Beattie TL. PloS one. 2009; 4(9):e7176.