Privé, Gil - University of Toronto - Department of Biochemistry

个人简介

I obtained my PhD from UCLA where I studied x-ray crystallography and DNA structure with Richard Dickerson. I then shifted my interests to protein structure and was a postdoc with Sung-Hou Kim at Berkeley, followed by a second postdoc position at UCLA in the labs of David Eisenberg and Ron Kaback. During this time, I got hooked on two research directions that I still pursue to this day – the family of BTB-domain containing proteins and membrane proteins/lipid binding proteins. In addition to my position in the Department of Biochemistry, I am a Senior Scientist at the Princess Margaret Cancer Centre.

近期论文

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Structure of Human Acid Sphingomyelinase Reveals the Role of the Saposin Domain in Activating Substrate Hydrolysis. Xiong ZJ, Huang J, Poda G, Pomès R, Privé GG. J Mol Biol. 2016 Jul 31;428(15):3026-42. Read Structural Insights into KCTD Protein Assembly and Cullin3 Recognition. Ji AX, Chu A, Nielsen TK, Benlekbir S, Rubinstein JL, Privé GG. J Mol Biol. 2016 Jan 16;428(1):92-107. Read Picodiscs for facile protein-glycolipid interaction analysis. Leney AC, Rezaei Darestani R, Li J, Nikjah S, Kitova EN, Zou C, Cairo CW, Xiong ZJ, Privé GG, Klassen JS. Anal Chem. 2015 Apr 21;87(8):4402-8. Read Ubiquitylome analysis identifies dysregulation of effector substrates in SPOP-mutant prostate cancer. Theurillat JP, Udeshi ND, Errington WJ, Svinkina T, Baca SC, Pop M, Wild PJ, Blattner M, Groner AC, Rubin MA, Moch H, Privé GG, Carr SA, Garraway LA. Science. 2014 Oct 3;346(6205):85-9. Read Adaptor protein self-assembly drives the control of a cullin-RING ubiquitin ligase. Errington WJ, Khan MQ, Bueler SA, Rubinstein JL, Chakrabartty A, Privé GG. Structure. 2012 Jul 3;20(7):1141-53 Read Structure of saposin A lipoprotein discs. Popovic K, Holyoake J, Pomès R, Privé GG Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):2908-12 Read PagP crystallized from SDS/cosolvent reveals the route for phospholipid access to the hydrocarbon ruler. Cuesta-Seijo JA, Neale C, Khan MA, Moktar J, Tran CD, Bishop RE, Pomès R, Privé GG. Structure. 2010 Sep 8;18(9):1210-9 Read A small-molecule inhibitor of BCL6 kills DLBCL cells in vitro and in vivo. Cerchietti LC, Ghetu AF, Zhu X, Da Silva GF, Zhong S, Matthews M, Bunting KL, Polo JM, Farès C, Arrowsmith CH, Yang SN, Garcia M, Coop A, Mackerell AD Jr, Privé GG, Melnick A. Cancer Cell. 2010 Apr 13;17(4):400-11. Read