Lee, Warren L. - University of Toronto - Department of Biochemistry

个人简介

Dr. Lee received his M.D. from the University of Toronto and was awarded the Cody Gold Medal. He completed residencies in Internal Medicine, Respirology, and Critical Care Medicine in Toronto. He then undertook research training in the Program in Cell Biology at the Hospital for Sick Children in the laboratory of Dr. Sergio Grinstein, completing a PhD in 2006. This was followed by postdoctoral training in Microbiology and Immunology at Weill Medical College of Cornell University (New York, NY) in the laboratory of Dr. Carl F. Nathan. His research focuses on the mechanisms of endothelial permeability.

近期论文

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A novel assay uncovers an unexpected role for SR-BI in LDL transcytosis. Armstrong S, Sugiyama M, Fung YY, Gao Y, Wang C, Levy AS, Azizi P, Roufaiel M, Zhu S-N, Neculai D, Yin C, Bolz S-S, Seidah N, Cybulsky M, Heit B, Lee WL. Cardiovascular Research 2015 (in press). Read Clathrin-dependent entry and vesicle-mediated exocytosis define insulin transcytosis across microvascular endothelial cells. Azizi PM, Zyla RE, Guan S, Wang C, Liu J, Bolz S-S, Heit B, Klip A, Lee WL Molecular Biology of the Cell 2015 Feb 15;26(4):740-50. doi: 10.1091/mbc.E14-08-1307. Epub 2014 Dec 24. Read The Tie2-agonist Vasculotide rescues mice from influenza virus infection Sugiyama MG, Armstrong SM, Wang C, Hwang D, Leong-Poi H, Advani A, Advani S, Szaszi K, Tabuchi A, Kuebler WM, Van Slyke P, Dumont DJ, Lee WL Scientific Reports 2015| 5:11030 | DOI: 10.1038/srep11030 Read Influenza primes human lung microvascular endothelium to leak upon exposure to Staphylococcus aureus Wang C*, Armstrong SM*, Sugiyama MG, Tabuchi A, Krauszman A, Kuebler WM, Mullen B, Advani S, Advani A, Lee WL American Journal of Respiratory Cell and Molecular Biology (2015), in press. Influenza Infects Lung Microvascular Endothelium Leading to Microvascular Leak: Role of Apoptosis and Claudin-5. Armstrong SM, Wang C, Tigdi J, Si X, Dumpit C, Charles S, Gamage A, Moraes, TJ, & Lee WL Plos One (2012). 7(10):e47323 Read Co-regulation of transcellular and paracellular leak across microvascular endothelium by dynamin and Rac. Armstrong SM, Khajoee V, Wang C, Wang T, Tigdi J, Yin J, Kuebler WM, Gillrie M, Davis SP, Ho M, Lee WL The American Journal of Pathology (2012), 180(3), 1308–23 Broken barriers: a new take on sepsis pathogenesis. Goldenberg NM, Steinberg BE, Slutsky AS, Lee WL Science Translational Medicine 2011, 3(88), 88ps25