Enenkel, Cordula - University of Toronto - Department of Biochemistry

个人简介

Cordula Enenkel was born and raised in Stuttgart, Germany. As a graduate student in Dieter H. Wolf’s laboratory at the University of Stuttgart, she worked on two ubiquitous proteases. She discovered the caspase-like activity of the proteasome and the aminopeptidase bleomycin hydrolase. Her PhD work was supported by the Landesgraduiertenförderung Baden-Württemberg. After receiving her PhD in 1993, she joined Günter Blobel’s laboratory at the Howard Hughes Medical Institute of the Rockefeller University in New York where she was supported by the German Research Foundation (DFG) and the Thyssen Foundation. During her post doc from 1994-1997, she investigated the classical nuclear transport pathway using importin / karyopherin αβ in yeast. Then, she moved to Berlin, Germany, where she worked as a group leader and lecturer in the Institute of Biochemistry of the Humboldt University / Charité headed by Peter-Michael Kloetzel. Here, she discovered the nuclear import pathway of proteasomes and quality control pathways of proteasome assembly. In 2002, she became Privatdozent (Habilitation), was involved in teaching Biochemistry and worked on the regulation of proteasome homeostasis. In 2011, she moved her laboratory to Toronto.

研究领域

Dr. Enenkel is interested in the dynamics of proteasomes. Proteasomes are mainly nuclear in dividing cells and sequestered into droplet-like organelles in the cytoplasm of quiescent cells. The organization of these proteasome droplets remains a mystery. Since most of our body’s cells are quiescent, it is important to understand the structure of proteasome droplets and their function with regard to the degradation of toxic proteins. Impaired proteasomal degradation of toxic proteins is associated with neurodegenerative diseases such as Alzheimer’s, Huntington’s and Parkinson’s.

近期论文

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Nuclear Transport of Yeast Proteasomes Enenkel, C. Biomolecules (2014) 4, 940-955 Read Proteasome Assembly Gu, Z.C. & Enenkel, C. Cell Mol. Life Sci. (2014) 71, 4729-4745 Read Proteasome Dynamics Enenkel, C. Biochim. Biophys. Acta (2014) 1843, 39-46 Read Blm10 facilitates nuclear import of proteasome core particles Weberruss, M.H., Savulescu, A.F., Jando, J., Bissinger, T., Harel, A., Glickman, M.H., Enenkel, C. EMBO J. (2013) 32, 2697-2707 Read Nuclear Import of Yeast Proteasomes Burcoglu, J., Zhao, L. Enenkel, C. Cells (2015) 4, 387-405 Read