Wilde, Andrew - University of Toronto - Department of Biochemistry

个人简介

Andrew Wilde hails form the UK and moved to North America for Post-Doctoral work with Frances Brodsky at UCSF where he discovered novel links between receptor tyrosine kinase signaling and endocytosis. Subsequently, he moved to the Carnegie Institution in Baltimore to work with Yixian Zheng where he discovered a chromosome based signaling pathway that spatially organizes a mitotic cell. Andrew moved to Toronto in 2001 where he held a Canada Research Chair in Cell Biology. Andrew has continued his work examining how signals spatially co-ordinate mitosis with a particular focus on the co-ordination of chromosome segregation with membrane re-organization during cytokinesis and the role of tumor suppressors in regulating this process to ensure genome stability.

研究领域

Our research focus is to understand how cells divide. In particular we focus on the role of cell division in tumor formation and oogenesis. We take a multi-faceted approach combining biochemistry and live imaging to analyze cell division in frog eggs, Drosophila embryos and mammalian cells.

近期论文

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Anillin-dependent organization of septin filaments promotes intercellular bridge elongation and Chmp4B targeting to the abscission site Matthew J. Renshaw, Jinghe Liu, Brigitte D. Lavoie and Andrew Wilde Open Biol.. 2014 4:130190 Read The BAR domain of Amphiphysin is required for pseudocleavage furrow tip (PFT)-tubule formation during cellularization in Drosophila embryos Jing Su, Brenda Chow, Gabrielle L. Boulianne, and Andrew Wilde Mol. Biol. Cell 2013 24: 1444-1453 Read Cleavage furrow organization requires PIP2-mediated recruitment of anillin Liu, J., Fairn, G.D., Ceccarelli, D.F., Sicheri, F. and Wilde A. Curr. Biol. 2012 22:64-69 Read The site of RanGTP generation can act as an organizational cue for mitotic microtubules. Zonis J, Wilde A. Biol Cell. 2011 103:421-34 Read Anillin-mediated targeting of peanut to pseudocleavage furrows is regulated by the GTPase Ran. Silverman-Gavrila RV, Hales KG, Wilde A. Mol Biol Cell. 2008 19:3735-44 Read Ran is required before metaphase for spindle assembly and chromosome alignment and after metaphase for chromosome segregation and spindle midbody organization. Silverman-Gavrila RV, Wilde A. Mol Biol Cell. 2006 17:2069-80 Read Ran modulates spindle assembly by regulating a subset of TPX2 and Kid activities including Aurora A activation. Trieselmann N, Armstrong S, Rauw J, Wilde A. J Cell Sci. 2003 116:4791-8 Read Ran localizes around the microtubule spindle in vivo during mitosis in Drosophila embryos. Trieselmann N, Wilde A. Curr Biol. 2002 12:1124-9 Read