Pomès, Régis - University of Toronto - Department of Biochemistry

个人简介

Régis Pomès obtained his PhD in theoretical chemistry with Andy McCammon, specialising in computer simulations of biomolecular systems. He then worked on the molecular mechanism of proton translocation in ion channels as a postdoc with Benoît Roux, before broadening his expertise in computational biophysics in the group of Ángel García at Los Alamos. In 1999 he moved to Toronto, where he has enjoyed developing an exciting collaborative research programme with a team of talented students and postdocs. He is interested in the development of computer simulation techniques and their application to studies of ion permeation in membrane proteins, protein-lipid interactions, as well as a broad range of problems pertaining to the solvation, binding, and aggregation of proteins in folded or disordered states.

研究领域

The Pomès group specializes in the development of computational methods and their application to the study of biological processes. In particular, we seek to uncover the link between the structure, dynamics, and function of proteins. Our work is grounded in statistical mechanics, which provides a formal connection between microscopic and macroscopic length scales. We use computer simulations of molecular models to glean mechanistic insight at spatial and temporal resolutions that are difficult to attain experimentally. More specifically, we study systems of biological relevance with atomistic resolution over time scales extending from the femtosecond to the microsecond and beyond—9 to 11 orders of magnitude over which many important biological processes occur at the molecular level. We are interested in elucidating the physical basis for the structure and function of membrane proteins and in a variety of problems pertaining to protein folding, binding, and self-aggregation.

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Modification and periplasmic translocation of the biofilm exopolysaccharide poly-β-1,6-N-acetyl-D-glucosamine Little DJ, Li G, Ing C, DiFrancesco BR, Bamford NC, Robinson H, Nitz M, Pomès R, Howell PL Proc. Natl. Acad. Sci. USA, 111:11013-11018 (2014) Read Indolicidin Binding Induces Thinning of a Lipid Bilayer Neale C, Hsu JCY, Yip CM, Pomès R Biophys. J. 106:L29-31 (2014) Read Catalysis of Na+ Permeation in Bacterial Sodium Channel NavAb Chakrabarti N, Ing C, Payandeh J, Zheng N, Catterall WA, Pomès R Proc. Natl. Acad. Sci. USA 110:11331-11336 (2013) Read Construction and Validation of a Homology Model of the Human Voltage-Gated Proton Channel hHv1 Kulleperuma K, Smith SME, Morgan D, Musset B, Holyoake J, Chakrabarti N, Cherny VV, DeCoursey TE, Pomès R J. Gen. Physiol. 141:445-465 (2013) Read Structural investigations of the magnesium transport system CorA point to sequential allosteric regulation Pfoh R, Li A, Chakrabarti N, Payandeh J, Pomès R, Pai EF Proc. Natl. Acad. Sci. USA 109:18809-18814 (2012) Read Structural Disorder and Protein Elasticity Rauscher S, Pomès R Adv Exp Med Biol. 725:159-83 (2012) Read The Structure of Saposin A Lipoprotein Discs Popovic K, Holyoake J, Pomès R, Privé GG Proc. Natl. Acad. Sci. USA 109:2908-2912 (2012) Read Statistical Convergence of Equilibrium Properties in Simulations of Molecular Solutes Embedded in Lipid Bilayers Neale C, Bennett WFD, Tieleman DP, Pomès R J. Chem. Theory Comput. 7:4175–4188 (2011)