Watts, Joel C. - University of Toronto - Department of Biochemistry

个人简介

I obtained my BSc in Biochemistry from the University of Western Ontario in 2003 and my graduate studies were conducted in the lab of Dr. David Westaway at the University of Toronto. My graduate work involved the first characterization of the novel prion protein family member Shadoo. After receiving my PhD in 2008 I pursued postdoctoral studies in the lab of Nobel Laureate Dr. Stanley Prusiner at the University of California San Francisco. My postdoctoral work focused on developing new transgenic mouse models of prion disease as well as exploring the prion-like properties of Aβ and α-synuclein, which are implicated in the pathobiology of Alzheimer’s disease and Parkinson’s disease, respectively. In 2014 I started my own lab at the Tanz Centre for Research in Neurodegenerative Diseases with a cross-appointment within the Department of Biochemistry.

研究领域

My research interests include the prion diseases and related human neurodegenerative disorders such as Alzheimer’s disease. My research focuses on developing improved mouse and cellular models of human neurodegenerative diseases that can be used to study the biology of these illnesses and as tools for developing novel therapeutics.

近期论文

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Towards authentic transgenic mouse models of heritable PrP prion diseases Watts JC, Giles K, Bourkas MEC, Patel S, Oehler A, Gavidia M, Bhardwaj S, Lee J, Prusiner SB Acta Neuropathologica 2016 132(4): 593-610. Read Guinea pig prion protein supports rapid propagation of bovine spongiform encephalopathy and variant Creutzfeldt-Jakob disease prions Watts JC, Giles K, Saltzberg DJ, Dugger BN, Patel S, Oehler A, Bhardwaj S, Sali A, Prusiner SB Journal of Virology 2016 90(21): 9558-9569. Read Modulation of Creutzfeldt-Jakob disease propagation by the A224V mutation Watts JC, Giles K, Serban A, Patel S, Oehler A, Bhardwaj S, Guan S, Greicius M, Miller BL, DeArmond SJ, Geschwind MD, Prusiner SB Annals of Neurology 2015 78(4): 540-553. Read Serial propagation of distinct strains of Aβ prions from Alzheimer’s disease patients Watts JC, Condello C, Stöhr J, Oehler A, Lee J, DeArmond SJ, Lannfelt L, Ingelsson M, Giles K, Prusiner SB PNAS 2014 111(28): 10323-10328. Read Evidence that bank vole PrP is a universal acceptor for prions Watts JC, Giles K, Patel S, Oehler A, DeArmond SJ, Prusiner SB PLoS Pathogens 2014 10(4): e1003990. Read Transmission of multiple system atrophy prions to transgenic mice Watts JC, Giles K, Oehler A, Middleton LT, Dexter DT, Gentleman SM, DeArmond SJ, Prusiner SB PNAS 2013 110(48): 19555-19560. Read Purified and synthetic Alzheimer’s amyloid beta (Aβ) prions Stöhr J*, Watts JC*, Mensinger ZL, Oehler A, Grillo SK, DeArmond SJ, Prusiner SB, Giles K *Equal contribution PNAS 2012 109(27): 11025-11030. Read Spontaneous generation of rapidly transmissible prions in transgenic mice expressing wild-type bank vole prion protein Watts JC, Giles K, Stöhr J, Oehler A, Bhardwaj S, Grillo SK, Patel S, DeArmond SJ, Prusiner SB PNAS 2012 109(9): 3498-3503. Read