Trimble, William S. - University of Toronto - Department of Biochemistry

个人简介

Dr. Trimble received his Ph.D. in 1987 from the University of Toronto where he worked in the laboratory of Dr. Nobumichi Hozumi studying the mechanisms responsible for cellular transformation by the ras oncogene. He then went on to do postdoctoral work with Dr. Richard Scheller at Stanford University where he discovered the VAMP protein, the first member of the family of proteins now known as SNAREs that are responsible for the fusion of membranes in virtually all cellular contexts. In 1990 he moved back to the University of Toronto and in 1996 to the Hospital for Sick Children where he is a Senior Scientist and Head of the Cell Biology Program. His research focuses on the basic mechanisms controlling a variety of cellular processes, such as membrane transport, lipid metaobolism and cell division, and how these go awry in diseases such as atherosclerosis and cancer.

近期论文

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The cellular response to small molecules is defined by biological and structural chemogenomic signatures. Lee, AY, RP St. Onge, M Proctor, IM. Wallace, AH. Nile, PA. Spagnuolo, Y Jitkova, M Gronda, Y Wu, MK. Kim, K Cheung-Ong, N Torres, ED. Spear, M Han, U Schlecht, S Suresh,G Duby, LE. Heisler, A Surendra, E Fung, M Urbanus,M Gebbia, E Lissina, M Miranda, JH Chiang, AM Aparicio, M Zeghouf, RW Davis, J Cherfils, M Boutry, CA.Kaiser, CL Cummins, WS Trimble, GW Brown, AD Schimmer, VA Bankaitis, C Nislow, GD. Bader and, Guri Giaever. Science 344(6180):208-11 (2014) Read Estey, MP, C Di Ciano-Oliveira, CD. Froese, JD. Steels, DW. Litchfield & WS Trimble Mitotic regulation of SEPT9 by Cdk1 and Pin1 is important for the completion of cytokinesis. J. Biol. Chem. 288:30075-86 (2013) Read Structure of the scavenger receptor LIMP-2/LGP85 provides functional insights; implications for SR-B1 and CD36. Neculai, D, Schwake, M, Ravichandran M, Neculai, M, Loppnau, P, , Seitova A, Collins, R, Plumb, J, Zunke, F, Peters, J, Trimble, WS, Saftig, P, Grinstein, S, Dhe Paganon, S. Nature 504:172-6 (2013) Read Multimolecular signaling complexes enable Syk-mediated signaling of CD36 internalization. Heit, B, H Kim, G Cosio, D Castaño, R Collins, CA Lowell, KC Cain, WS Trimble, and S Grinstein Developmental Cell 24:372-83 (2013) Read Uncovering the principles that control septin-septin interactions. Kim, MS, CD Froese and WS Trimble J. Biol. Chem. 287(36):30406-13 (2012) Read SEPT9 occupies the terminal positions in septin octamers and mediates polymerization-dependent functions in abscission Kim, MS, CD Froese, MP Estey and WS Trimble J. Cell Biol. 195:815-26 (2011) Read The cytoskeleton reduces the diffusional dimensionality of CD36 promoting its aggregation and signaling. Jaqaman, K, H Kuwata, N Touret, R. Collins, W Trimble, G Danuser and S Grinstein. Cell 146:593-606 (2011) Read Distinct roles of septins in cytokinesis: SEPT9 regulates exocyst localization during abscission. Estey, MP, C DiCiano-Oliveira, MT Bejide, CD Froese, and WS Trimble J. Cell Biol. 191:741-749 (2010) Read