Palazzo, Alexander F. - University of Toronto

个人简介

Alexander Francis Palazzo was born and raised in Montreal, Canada. As a graduate student in Gregg Gundersen’s laboratory at Columbia University, he discovered two major pathways that regulate cell polarity in migrating fibroblasts. After receiving his PhD in 2003, he moved to Tom Rapoport’s laboratory at Harvard Medical School where he was a Jane Coffin Childs Postdoctoral Fellow. There he investigated how newly synthesized mRNA is exported from the nucleus and then targeted to specific sites in the cytoplasm of mammalian cells, such as the surface of the endoplasmic reticulum. In 2009 he started his lab in the Biochemistry Department. Besides his work on mRNA export and localization, Dr. Palazzo is interested in how biological information is extracted from the mammalian genome. He has published several well regarded reviews on how mRNA processing and nuclear export is used to sort useful information from a genome that is mostly filled with junk DNA. Dr. Palazzo has received several awards and is an editorial board member of the journal PLoS One.

近期论文

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Splicing promotes the nuclear export of β-globin mRNA by overcoming nuclear retention elements Akef A, Lee ES, Palazzo AF RNA 2015 21(11):1908-20. Read mRNA encoding Sec61β, a tail-anchored protein, is localized on the endoplasmic reticulum Cui XA, Zhang H, Ilan L, Liu AX, Kharchuk I, Palazzo AF J Cell Sci. 2015 128(18):3398-410. Read Non-coding RNA: what is functional and what is junk? Palazzo AF, Lee ES. Front Genet. 2015 6(2):1-11. Read The consensus 5' splice site motif inhibits mRNA nuclear export. Lee ES, Akef A, Mahadevan K, Palazzo AF. PLoS One. 2015 10(3):e0122743. Read Sumoylation is Required for the Cytoplasmic Accumulation of a Subset of mRNAs. Zhang H, Mahadevan K, Palazzo AF. Genes. 2014 5(4):982-1000. Read The case for junk DNA. Palazzo AF, Gregory TR. PLoS Genetics 2014 10(5):e1004351. Read Localization of mRNAs to the endoplasmic reticulum. Cui XA, Palazzo AF. Wiley Interdiscip Rev RNA. 2014 5(4):481-92. Read RanBP2/Nup358 potentiates the translation of a subset of mRNAs encoding secretory proteins. Mahadevan K, Zhang H, Akef A, Cui XA, Gueroussov S, Cenik C, Roth FP, Palazzo AF PLoS Biology 2013 11(4):e1001545. Read