Kelley, Shana O. - University of Toronto - Department of Biochemistry

个人简介

Dr. Shana Kelley is a Distinguished Professor of Biochemistry, Pharmaceutical Sciences, Chemistry, and Biomedical Engineering at the University of Toronto. Dr. Kelley received her Ph.D. from the California Institute of Technology and was a NIH postdoctoral fellow at the Scripps Research Institute. Her research interests are the development of new technologies for clinical diagnostics and drug delivery. Dr. Kelley’s work has been recognized with a variety of distinctions, including being named one of ‘Canada’s Top 40 under 40′, a NSERC E.W.R. Steacie Fellow, and the 2011 Steacie Prize. She has also been recognized with the Pittsburgh Conference Achievement Award, an Alfred P. Sloan Research Fellowship, a Camille Dreyfus Teacher-Scholar award, a NSF CAREER Award, a Dreyfus New Faculty Award, and was also named a “Top 100 Innovator” by MIT’s Technology Review. She is a founder of two molecular diagnostics companies, GeneOhm Sciences (acquired by Becton Dickinson in 2005) and Xagenic Inc. Education 1999 Ph.D. (Chemistry) California Institute of Technology Professional Appointments 2018 - present University Professor University of Toronto, Departments of Chemistry, Pharmaceutical Sciences, Biochemistry, Institute for Biomaterials and Biomedical Engineering 2007 - 2018 Professor University of Toronto, Departments of Chemistry, Pharmaceutical Sciences, Biochemistry, Institute for Biomaterials and Biomedical Engineering 2008 - 2011 Director, Division of Biomolecular Sciences, Faculty of Pharmacy University of Toronto 2006 Professor Boston College, Department of Chemistry 2000 - 2006 Assistant Professor Boston College, Department of Chemistry 1999 - 2000 NIH Postdoctoral Fellow Scripps Research Institute, Department of Cell and Molecular Biology

研究领域

Development of Novel Molecules and Devices to Measure Biological Activity The overarching theme of our research program is the development of novel molecules and devices enabling biological activities to be measured in new ways. The projects underway involve aspects of diverse disciplines ranging from biomolecular chemistry, molecular biology, and cell biology to materials science,

近期论文

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“Reagentless Biomolecular Analysis Using a Nanoscale Molecular Pendulum.” J. Das, S. Gomis, J.B. Chen, H. Yousefi, S.Ahmed, A. Mahmud, W. Zhou, E. H. Sargent, S.O. Kelley Nature Chemistry, 2021, in press, doi: 10.1101/2020.04.02.020453v1. link “Strategies for Biomolecular Analysis and Continuous Physiological Monitoring.” A. Clifford, J. Das, H. Yousefi, A. Mahmud, J.B. Chen, S.O. Kelley Journal of the American Chemical Society, 2021, in press, doi.org/10.1021/jacs.0c13138 link “Detection of SARS-CoV-2 Viral Particles using Direct, Reagent-Free Electrochemical Sensing.” H. Yousefi, A. Mahmud, D. Chang, J. Das, S. Gomis, J.B. Chen, H. Wang, T. Been, L.Yip, E. Coomes, Z. Li, S. Mubareka, A. McGeer, N. Christie, S. Gray-Owen, A. Cochrane, J.M. Rini, E.H. Sargent, S.O. Kelley Journal of the American Chemical Society, 2021, 143, 1722-1727. link “Ultrasensitive Detection of Rare Leukemic B Cells in T Cell Populations.” Z. Wang, E.H. Sargent, S.O. Kelley Anal. Chem., 2021, 93, 2327-2335. link “Fluorescent Droplet Cytometry for On-Cell Phenotype Tracking.” X. Yang, W. liu, D. C.-H. Chan, S.U. Ahmed, H. Wang, Z. Wang, C.R. Nemr, S.O. Kelley Journal of the American Chemical Society, 2020, 142, 14805–14809. link “A Multiplexed, Electrochemical Interface for Gene Circuit-Based Sensors.” P. Sadat Mousavi, S.J. Smith, J.B. Chen, M. Karlikow, A. Tinafar, W. Liu, D. Ma, A.A. Green, S.O. Kelley,* K. Pardee* Nature Chemistry, 2020, 12, 48-55. link “A New Era in Liquid Biopsy: From Genotype to Phenotype.” S.O. Kelley and K. Pantel, Clinical Chemistry, 2020, 66, 89-96. link "High-Performance Nucleic Acids Sensors for Liquid Biopsy Applications." J. Das and S.O. Kelley Angew. Chem. Intl. Ed. 2020, 59, 2554-2564. link “Analyzing Proteins at the Single-Cell Level: The Challenge of the Proteome.” M. Labib and S.O. Kelley Nature Reviews Chemistry, 2020, 4, 143-158. link “Nanostructured Architectures Promote the Mesenchymal–Epithelial Transition for Invasive Cells.” Z. Wang, F. Xia, M. Labib, M. Ahmadi, H. Chen, J. Das, S.U. Ahmed, S. Angers, E.H. Sargent, S.O. Kelley ACS Nano, 2020, 14, 5324-5336. link “Magnetic Ranking Cytometry: Profiling Rare Cells at the Single-Cell Level.” M. Labib, D.N. Philpott, Z. Wang, C. Nemr, J.B. Chen, E.H. Sargent, S.O. Kelley Accounts of Chemical Research, 2020, 53, 1445-1457. link “Regioselective Magnetization in Semiconducting Nanorods.” T.-T. Zhuang, Y. Li, X. Gao, M. Wei, F. P. García de Arquer, P. Todorović, J. Tian, G. Li, C. Zhang, X. Li, L. Dong, Y. Song, Y. Lu, X. Yang, L. Zhang, F. Fan, S.O. Kelley, S.-H. Yu, Z. Tang, E.H. Sargent Nature Nanotechnology, 2020, 15, 192-197. link “Efficient electrically powered CO2 to ethanol via suppression of deoxygenation” X. Wang, Z. Wang, F.P. García de Arquer, C.-T. Dinh, A. Ozden, Y.C. Li, D.-H. Nam, J. Li, Y.-S. Liu, J. Wicks, Z. Chen, M. Chi, B.Chen, Y.Wang, J. Tam, J.Y. Howe, A. Proppe, P. Todorović, F. Li, T.-T. Zhuang, C.M. Gabardo, A.R. Kirmani, C. McCallum, S.-F. Hung, Y. Lum, M. Luo, Y. Min, A. Xu, C.P. O’Brien, B. Stephen, B. Sun, A.H. Ip, L.J. Richter, S.O. Kelley, D. Sinton, E.H. Sargent. Nature Energy, 2020, 5, 478-486. link “Multi-cation perovskites prevent carrier reflection from grain surfaces” M.I. Saidaminov, K. Williams, M. Wei, A. Johnston, R. Quintero-Bermudez, M. Vafaie, J.M. Pina, A.H. Proppe, Y. Hou, G. Walters, S.O. Kelley, W.A. Tisdale, E.H. Sargent. Nature Materials, 2020, 19, 412-418. link “Efficient near-infrared light-emitting diodes based on quantum dots in layered perovskite” L. Gao, L.N. Quan, F.P. García de Arquer, Y. Zhao, R. Munir, A. Proppe, R. Quintero-Bermudez, C. Zou, Z. Yang, M.I. Saidaminov, O. Voznyy, S. Kinge, Z. Lu, .O. Kelley, A. Amassian, J. Tang, E.H. Sargent. Nature Photonics, 2020, 14, 227-233. link “Catalyst synthesis under CO2 electroreduction favours faceting and promotes renewable fuels electrosynthesis” Y. Wang, Z. Wang, C.-T. Dinh, A. Li, J.,Ozden, M. Golam Kibria, A. Seifitokaldani, C.-S. Tan, C.M. Gabardo, M. Luo, H. Zhou, F. Li, Y. Lum, C. McCallum, Y. Xu, M. Liu, A. Proppe, A. Johnston, P. Todorovic, T.-T. Zhuang, D. Sinton, S.O. Kelley, E.H. Sargent. Nature Catalysis, 2020, 3, 98-106. link “Bioinspiration in light harvesting and catalysis” A.H. Proppe, Y.C. Li, A. Aspuru-Guzik, C.P. Berlinguette, C.J. Chang, R. Cogdell, A.G. Doyle, J. Flick, N.M. Gabor, R. van Grondelle, S. Hammes-Schiffer, S.A. Jaffer, S.O. Kelley, M. Leclerc, K. Leo, T.E. Mallouk, P. Narang, G.S. Schlau-Cohen, G.D. Scholes, A. Vojvodic, J.Y. Yang, E.H. Sargent. Nature Reviews Materials, 2020, 5, 828-846. link “High-Throughput Genome-Wide Phenotypic Screening via Immunomagnetic Cell Sorting.” B. Mair, P.M. Aldridge, R.S. Atwal, D. Philpott, M. Zhang, S.N. Masud, M. Labib, A.H.Y. Tong, E.H. Sargent, S. Angers, J. Moffat,* S.O. Kelley* Nature Biomed. Eng. 2019, 3, 796-805. link “Peptide-Functionalized Nanostructured Microarchitectures Enable Rapid Mechanotransductive Differentiation." Z. Wang, L. Zhang, M. Labib, H. Chen, M. Wei, M. Poudineh, B.J. Green, B. Duong, J. Das, S. Ahmed, E.H. Sargent, S.O. Kelley, ACS Applied Materials and Interfaces 2019, 11, 41030-41037. link “Potential-Responsive Surfaces for Dynamic Manipulation of Cell Adhesion, Release and Differentiation.” L. Zhang, Z. Wang, J. Das, M. Labib, S. Ahmed, E.H. Sargent, S.O. Kelley, Angew. Chem. Intl. Ed. 2019, 58, 14519-14523. link