Steipe, Boris - University of Toronto - Department of Biochemistry

个人简介

Boris Steipe was born in Munich, Germany where he graduated from the medical school of the Ludwig-Maximilians University in 1985. He joined Andreas Plückthun’s lab at the Gene Center of the University for his PhD thesis on the recombinant expression and structure determination of an immunoglobulin fragment. Subsequently, his interests turned to protein engineering, and he joined Robert Huber’s Department at the Max-Planck Institute for Biochemistry in Martinsried, Germany in 1990. It was there that his “Canonical Sequence Approximation” – the hypothesis that sequence propensities can be used to predict stability changes in a very general way was first formulated. Steipe was appointed Research Fellow at the Gene Center of the University, in 1990 and where his group worked on the rational stabilisation of immunoglobulin domains, on sequence determinants of protein folding and on the interplay of the protein matrix with the fluorophore in Green Fluorescent Protein; he was awarded his Habilitation in Biochemistry at the Faculty for Chemistry and Pharmacy of the University in 2000, when he was appointed as lecturer. In 2001 Steipe moved to Toronto where he holds an appointment as associate professor in the Department for Biochemistry and the Department for Molecular Genetics, University of Toronto. His present work focusses on structural bioinformatics with an emphasis on structural motifs.

研究领域

The cohesive element of my research projects is the quest to understand complexity in biomolecular systems. Complexity arises from a context dependent behaviour of system components and we observe complexity in many hierarchical layers of structure formation and generation of function, from the genome to the living cell. My work mainly focusses on proteins since protein folding is the quintessential paradigm of self-organising molecular systems. Based on our concepts to address complexity, my lab has developed strategies and algorithms to analyse proteins and engineer them in predictable ways.

近期论文

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schematikon: Detailed Sequence-Structure Relationships from Mining a Non-redundant Protein Structure Database Boris Steipe and Bhooma Thiruv Bioinformatics Research And Applications - Springer Lecture Notes in Computer Science Volume 8492, 2014, pp 357-366 Read Nh3D: a reference dataset of non-homologous protein structures Bhooma Thiruv, Gerald Quon, S. Adrian Saldanha and Boris Steipe BMC Struct Biol. 2005 Jul 12;5:12. Read Consensus-based engineering of protein stability: from intrabodies to thermostable enzymes. Boris Steipe Methods Enzymol. 2004;388:176-86. Read