Keeley, Fred W. - University of Toronto - Department of Biochemistry

个人简介

Fred Keeley was born and raised in Winnipeg where he completed an undergraduate degree in Chemistry and a PhD in Pharmacology at the University of Manitoba. He spent two years as a Post-Doctoral fellow at the British Agricultural Research Council research establishment near Bristol, England, followed by a Post- Doctoral fellowship in the Department of Biochemistry at the Hospital for Sick Children. He joined the staff of the Research Institute of the Hospital for Sick Children in 1973, and is currently a Senior Scientist in the Molecular Structure and Function Program. From 1995 to 2013 he served as Associate Chief of Research at the Hospital for Sick Children, and held the Heart and Stroke Foundation of Ontario/Robert M. Freedom Chair in Cardiovascular Science at the Hospital for Sick Children from 2003 to 2008 and from 2008 to 2013. Dr. Keeley was first cross-appointed to the University of Toronto in 1975, and is currently Professor in the Department of Biochemistry and the Department of Laboratory Medicine and Pathobiology.

研究领域

Our laboratory is located on the 21st floor of the newly completed Peter Gilgan Centre for Research and Learning at the Hospital for Sick Children. Our general interest in sequence/structure/function relationships in elastomeric proteins such as elastin includes studies of the evolutionary history of elastins, regulation of expression of the protein in development and disease, the mechanisms for self-assembly of monomeric elastin into its polymeric form, and the effects of sequence variation, including polymorphisms and splice variants, on the elastomeric properties of the elastin polymer. Our structural studies have led to close collaborations involving computational chemistry, solid state and solution NMR, and bioinformatics.

近期论文

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Characterization of Lamprin, an Unusual Matrix Protein from Lamprey Cartilage. Implications for Evolution, Structure and Assembly of Elastin and Other Fibrillar Proteins P. Robson, G. M. Wright, E. Sitarz, A. Maiti, M. Rawat, J. H. Youson and F. W. Keeley J Biol Chem 268, 1440-1447 (1993) Read Identification of a GA-Rich Sequence as a Protein-Binding Site in the 3’UTR of Chicken Elastin mRNA with a Potential Role in the Developmental Regulation of Elastin mRNA Stability Y. Hew, Z. Grzelczak, C. Lau and F. W. Keeley J Biol Chem 275, 24857-64 (2000) Read Sequences and Domain Structures of Mammalian, Avian, Amphibian and Teleost Tropoelastins. Clues to the Evolutionary History of Elastins M. I. Chung, M. Miao, R. J. Stahl, E. Chan, J. Parkinson and F. W. Keeley Matrix Biology 25, 492-504 (2006) Read Proline and Glycine Control Protein Self-Organization into Elastomeric or Amyloid Fibrils S. Rauscher, S. Baud, M. Miao, F. W. Keeley, and R. Pomès Structure 14, 1667-1676 (2006) Read Fibrillins, Fibulins and MAGP Modulate the Kinetics and Morphology of In Vitro Self-Assembly of a Recombinant Elastin-like Polypeptide J. T. Cirulis, C. M. Bellingham, E. C. Davis, D. Hubmacher, D. Reinhardt, R. P. Mecham and F. W. Keeley Biochemistry 47, 12601-12613 (2008) Read Proline Periodicity Modulates the Self-Assembly Properties of Elastin-Like Polypeptides L. D. Muiznieks and F. W. Keeley J Biol Chem 285, 39779-39789 (2010) Read Polymorphisms in the Human Tropoelastin gene Modify In Vitro Self-Assembly and Mechanical Properties of Elastin-like Polypeptides D. He, M. Miao, E. Sitarz, L. Muiznieks, S. Reichheld, R. Stahl, F. W. Keeley and J. Parkinson PLoS ONE 7(9): e46130. doi:10.1371/journal.pone.0046130 (2012) Read Sequence and Domain Arrangements Influence Mechanical Properties of Elastin-Like Polymeric Elastomers M. Miao, E. Sitarz, C. M. Bellingham, E. Won and L. M. Muiznieks and F. W. Keeley Biopolymers 99, 392-407 (2012) Read