Chan, Hue Sun - University of Toronto - Department of Biochemistry

个人简介

Hue Sun Chan was born and raised in Hong Kong. Upon completing his undergraduate degree in physics there, he pursued graduate study in theoretical particle physics at UC Berkeley, specializing in regularization of quantum field theories. After receiving his PhD in 1987, he joined Ken Dill’s research group at UCSF, first as a postdoctoral fellow then as an adjunct faculty, and shifted his research interest to protein biophysics. As one of a few researchers who pioneered theoretical studies of protein folding in the late 1980s, Chan has made seminal contributions during his UCSF years. These include discovering that secondary-structure-like local order can be enhanced by global conformational compactness, developing simple exact lattice protein models such as the HP model that have been widely applied, characterizing the role of kinetic traps and their implications on the folding energy landscape, and coauthoring several influential reviews on folding. In 1998, he left San Francisco to take up his present appointment. After arriving in Toronto, Chan turned his attention to the physical origins of folding cooperativity. His research interests have also been broadened to include thermodynamics of solvent-mediated interactions, protein evolution, protein interactions involving intrinsically disordered proteins, and DNA topology (see Research Description). He has published more than 125 research papers, which have received a total of more than 12,000 citations (see complete list of publications and invited talks). He is an editorial board member of Proteins: Structure, Function & Bioinformatics.

研究领域

Our research involves both analytical and computational modeling. For the computational effort, we employ codes developed by ourselves for coarse-grained biomolecular modeling as well as common molecular dynamics packages. Computational facilities available to us include our own local cluster (pictured above, right) and resources allotted by Compute Canada.

近期论文

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Sequence-Specific Polyampholyte Phase Separation in Membraneless Organelles. Y.-H. Lin, J. D. Forman-Kay and H.S. Chan Physical Review Letters 117:178101 (2016). Read Theoretical Insights into the Biophysics of Protein Bi-Stability and Evolutionary Switches. T. Sikosek, H. Krobath and H.S. Chan PLoS Computational Biology 12(6):e1004960 (2016) Read Theoretical Perspectives on Nonnative Interactions and Intrinsic Disorder in Protein Folding and Binding. T. Chen, J. Song and H.S. Chan Current Opinion in Structural Biology 30, 32-42 (2015). Read Native Contact Density and Nonnative Hydrophobic Effects in the Folding of Bacterial Immunity Proteins. T. Chen and H.S. Chan PLoS Computational Biology 11(5): e1004260 (2015). Read Biophysics of Protein Evolution and Evolutionary Protein Biophysics. T. Sikosek and H.S. Chan Journal of the Royal Society Interface 11, 20140419 (2014). Read Pressure-Dependent Properties of Elementary Hydrophobic Interactions: Ramifications for Activation Properties of Protein Folding. C.L. Dias and H.S. Chan Journal of Physical Chemistry B 118, 7488-7509 (2014). Read Polycation-π Interactions are a Driving Force for Molecular Recognition by an Intrinsically Disordered Oncoprotein Family. J. Song, S.C. Ng, P. Tompa, K.A.W. Lee and H.S. Chan PLoS Computational Biology 9(9): e1003239 (2013). Read Transition Paths, Diffusive Processes, and Preequilibria of Protein Folding. Z. Zhang and H.S. Chan Proceedings of the National Academy of Sciences, USA 109, 20919-20924 (2012). Read